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New non-immunizing, paraspecific vaccines from attenuated pox viruses developed.
2003 APR 2 - (NewsRx.com & NewsRx.net) -- A new type of non-immunizing, paraspecific vaccines have been developed from attenuated pox viruses.
According to recent research from Germany, "The various research periods leading to the development of paraspecific vaccines are described. Paraspecific vaccines are new, pyrogen-free, non-toxic preparations that contain non-immunizing antigens and can be used to generate endogenic protective, non-antigen specific mechanisms in the sense of paramunization in humans and animals."
"They consist of highly attenuated and inactivated (0.05% Betapropiolactone) virus strains of various poxvirus genera," said A. Mayr at Ludwig-Maximilians-University of Munich. "They activate the T helper cells and cellular elements of the paraspecific (innate) immune system and initiate the associated production and release of cytokines (cytokine cascade) with the goal of eliminating dysfunctions of the immune systems, rapidly enhancing the individual's non-pathogen- and non-antigen-specific defenses and exerting a regulatory effect on the interplay between the immune, hormone, nervous and vascular systems (signal-transduction mediators). They can be used systemically (intramuscularly) and locally (mucous membranes, skin)."
Mayr reported that "immunization with paraspecific vaccines does not lead to postvaccinal ...
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Source: HighBeam Research, New non-immunizing, paraspecific vaccines from attenuated pox viruses...