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Skeletal muscle can be used for nonviral gene delivery.
2003 MAR 19 - (NewsRx.com & NewsRx.net) -- Skeletal muscle is a virtual protein factory and can be used for non-viral gene delivery.
"Ever since the publication of the first reports in 1990 using skeletal muscle as a direct target for expressing foreign transgenes, an avalanche of papers has identified a variety of proteins that can be synthesized and correctly processed by skeletal muscle," researchers in England report.
"The impetus to the development of such applications is not only amelioration of muscle diseases, but also a range of therapeutic applications, from immunization to delivery of therapeutic proteins, such as clotting factors and hormones," said Q.L. Lu and collaborators at the Imperial College of Science, Technology, and Medicine in London. "Although the most efficient way of introducing transgenes into muscle fibers has been by a variety of recombinant viral vectors, there are potential benefits in the use of nonviral vectors."
The researchers concluded, "In this ...
- Skeletal muscle can be used for nonviral gene delivery.
- Newspaper article from: Gene Therapy Weekly March 20, 2003 700+ words
...delivery of naked plasmid DNA to skeletal muscle and highlight the options available...colleagues published their study in Gene Therapy (Non-viral gene delivery in skeletal muscle: a protein factory. Gene Therapy, 2003;10(2):131-142...
- Purdue Researchers Find 'Switch' for Skeletal-Muscle Atrophy.
- News wire article from: AScribe Health News Service May 24, 2006 700+ words
...found atrophy of skeletal muscle in mice could...inhibited with both gene therapy and drug treatment...protein in the skeletal muscle," Pond said...gene into the skeletal muscle that resulted...limited. Because gene therapy is not yet a...
- Electroporation facilitates gene transfer into adult skeletal muscle myofibers.
- Newspaper article from: Gene Therapy Weekly February 12, 2004 700+ words
...electrotransfer of genes in adult skeletal muscle fibers by a protocol...great potential for gene therapy, as well as for basic...myofibers of adult skeletal muscle. Biochem Biophys Res...of Biotechnology and Gene Therapy. This article was...
- Skeletal muscle progenitor cells are bone marrow derived with different fates.
- Newspaper article from: Gene Therapy Weekly March 6, 2003 700+ words
...Medicine, Center for Cell and Gene Therapy. "Non-SP cells were also derived...progenitors are resident within skeletal muscle, are derived from bone marrow...Medicine, Center for Cell and Gene Therapy, Houston, TX 77030, USA. To...
- Skeletal muscle differentiation potential of adult BM cells may lead to therapy.
- Newspaper article from: Gene Therapy Weekly June 24, 2004 700+ words
...NewsRx.net) -- Skeletal muscle differentiation potential...that cells with skeletal muscle differentiation potential...Experimental Cell Research (Skeletal muscle differentiation potential...article was prepared by Gene Therapy Weekly editors from...
- Skeletal muscle progenitor cells are bone marrow derived with different...
- Magazine article from: Stem Cell Week March 3, 2003 700+ words
...Medicine, Center for Cell and Gene Therapy. "Non-SP cells were also derived...progenitors are resident within skeletal muscle, are derived from bone marrow...Medicine, Center for Cell and Gene Therapy, Houston, TX 77030, USA. To...
- GAMT deficiency causes biochemical adaptations in brain and skeletal muscle.
- Newspaper article from: Gene Therapy Weekly June 24, 2004 700+ words
...phosphate in heart, skeletal muscle and brain. These...adaptations in brain and skeletal muscle. It is associated...in brain, heart, skeletal muscle and other organs...article was prepared by Gene Therapy Weekly editors from...
- HGF gene transfer by electroporation into skeletal muscle is workable.
- Newspaper article from: Gene Therapy Weekly January 2, 2003 700+ words
...the HGF gone into skeletal muscle was an effective...electroporation into skeletal muscle is feasible and effective...growth factor to skeletal muscle prevents changes...Transplantation, Gene Therapy, Gene Transfer...
- Attenuated acute liver injury in mice by naked hepatocyte growth factor gene...
- Magazine article from: Gut Xue, F. Takahara, T. Yata, Y. Minemura, M. Morioka, C.Y. Takahara, S. Yamato, E. Dono, K. Watanabe, A. April 1, 2002 700+ words
...mechanism remains unknown. Recently, HGF gene therapy was tested in a rat model of liver...transfected gene can be attained in skeletal muscle cells due to their postmitotic nature...method to transfer the HGF gene into skeletal muscle in viva and then determined its protective...
- Transcutaneous ultrasound augments naked DNA transfection of skeletal muscle.
- Newspaper article from: Gene Therapy Weekly January 23, 2003 700+ words
...Transcutaneous ultrasound augments naked DNA transfection of skeletal muscle. Mol Ther, 2002;6(5):576-583). For additional...Technology, Angiogenesis. This article was prepared by Gene Therapy Weekly editors from staff and other reports.
Source: HighBeam Research, Skeletal muscle can be used for nonviral gene delivery.