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Trial results are important step forward in developing effective vaccine.
2003 MAR 19 - (NewsRx.com & NewsRx.net) -- Preliminary results of a large-scale trial of a candidate AIDS vaccine announced by the U.S.-based biotechnology company VaxGen suggest that it is possible to protect some individuals from HIV infection.
The trial of the company's AIDSVAX vaccine appears to show a protective effect among non-Caucasian populations, especially African Americans, although sample sizes were small. However, for the majority of the participants, who were Caucasians, the effect of the vaccine was minimal.
The company stressed, however, that the results only represent findings from an initial analysis. Additional studies will be conducted over the coming weeks to further clarify the data.
"These results are promising. The trial provides clear evidence that a vaccine can work," said Dr. Peter Piot, executive director of UNAIDS. "However, there is an urgent need for more targeted research to find out why the candidate vaccine only seems to work in certain population sub-groups. In the meantime, we must continue to expand existing prevention efforts, which have proved their effectiveness when they are implemented at full scale."
This trial vaccine is a promising first step, but an effective vaccine providing widespread protection is still not on the horizon. The AIDSVAX Phase III trial was the first large-scale human trial of an HIV vaccine. The trial was made possible because of the involvement of over 5400 volunteers from the United States, Canada, and the Netherlands, the majority of whom were men who have sex with men.
Phase III trials, which involve thousands of volunteers, focus on whether a candidate vaccine is effective and can safely protect people. These are only conducted once Phase I and II trials have ensured that the vaccine is safe and produces an immune response against the virus.
The vaccine used in this trial was designed to reduce susceptibility to infection with HIV subtype B, which is prevalent in the Americas, ...
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Source: HighBeam Research, Trial results are important step forward in developing effective...