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DNA immunization offers new opportunities in vaccine research.(Brief Article)

Vaccine Weekly

| March 19, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 MAR 19 - (NewsRx.com & NewsRx.net) -- DNA immunization offers new opportunities in vaccine research.

"A novel class of vaccines, based on the immunization with 'naked' DNA, may hold the promise of protecting against human disease without the disadvantages associated with vaccines presently used, and may help to prevent infections which are not curable today," researchers in Germany report.

"Direct intramuscular or intradermal inoculation of plasmid DNA encoding sequences of viral proteins results in the synthesis of these proteins, causing humoral and/or cellular immune responses in the recipient," stated A. Henke at Friedrich-Schiller University. "Several advantages are associated with DNA immunization, e.g., cheap to produce, heat stability, amenable to genetic manipulation, mimic viral infection, and no risk of reversion to pathogenicity. Nevertheless, some concerns remain regarding their safety, e.g., the possible integration of plasmid DNA ...

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Source: HighBeam Research, DNA immunization offers new opportunities in vaccine research.(Brief...

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