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Viral transcriptional regulator elicits antibody response.(Brief Article)
2003 MAR 19 - (NewsRx.com & NewsRx.net) -- Viral transcriptional regulator elicited an antibody response.
"The E2 transcriptional activator of the human papillomavirus regulates the expression of most viral transcripts. Its binding to specific target DNA sequences involves large conformational changes in the interacting macromolecules," researchers in Argentina report.
"The high stability of the E2:DNA complex prompted us to analyze the role of macromolecular interactions and adjuvant emulsions in the appearance of conformation-specific antibodies," said M. Laura Cerutti and colleagues at the University of Buenos Aires. "We demonstrate that immunization with free or DNA-complexed E2 emulsified in an oil-in-water adjuvant elicits a humoral response shifted to the recognition of discontinuous epitopes. Epitope mapping and functional analysis of the generated anti-E2 mAbs reveals that two separate antibodies populations can be obtained: ...
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Source: HighBeam Research, Viral transcriptional regulator elicits antibody response.(Brief...