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Exposure to a solvent alternative causes ovarian dysfunction in rats.(1-bromopropane )
2003 MAR 13 - (NewsRx.com & NewsRx.net) -- Exposure to a solvent alternative causes ovarian dysfunction in rats.
According to a study from Japan, "although 1-bromopropane has been used in chemical and electronic industries as an alternative to ozone layer-depleting solvents, its toxicity on female reproductive organs has not been fully elucidated. The aim of this experiment was to determine the effect of 1-bromopropane on female reproductive function in rats."
"Forty female Wistar rats were divided into four equal groups. Each group was exposed daily to 0, 200, 400, or 800 ppm of 1-bromopropane for eight hours a day. After exposure for 7 weeks, all rats in the 800-ppm group became seriously ill and were sacrificed during the 8th week. The other dose groups were exposed for 12 weeks," stated T. Yamada and coauthors, Nagoya University, Graduate School of Medicine.
"In the 800-ppm group, but not in the other two exposed groups, body weight was significantly less than the control at each time point from 2 to 7 weeks after the beginning of exposure. Tests of vaginal smears showed a significant increase in the number of irregular estrous cycles with extended diestrus in the 400- and 800-ppm groups," they reported.
"Histopathological examination of the ovary showed a significant ...
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- Exposure to a solvent alternative causes ovarian dysfunction in rats.
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