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Ultra-short term prophylaxis effective for laparotomic gynecologic surgery patients.(amoxicillin-clavulanic acid and cefazolin compared)
2003 MAR 13 - (NewsRx.com & NewsRx.net) -- Ultra-short term prophylaxis can effectively prevent infectious morbidity after laparotomic gynecologic operations.
Researchers in Italy conducted a study "to compare two antimicrobial regimens, amoxicillin-clavulanic acid with cefazolin as ultra-short term prophylaxis in laparotomic gynecologic surgery."
"Patients were randomly allocated to receive a single dose of amoxicillin-clavulanic acid (2.2 g) [Group A] or cefazolin (2 g) [Group B] 30 minutes before surgery," explained G. Cormio and colleagues, Universita degli Studi di Bari. "Each patient was assessed daily until discharge for fever and the presence of infection of the surgical wound, urinary tract and respiratory tract."
"In the amoxicillin-clavulanic acid (Group A) and cefazolin (Group B) groups, overall 258 and 253 patients, respectively were evaluable for prophylactic efficacy at hospital discharge," according to the report. "Infectious complications were infrequent in both arms."
"Febrile morbidity occurred in 16 (6.3%) and 21 (8.1%) patients respectively in the amoxicillin-clavulanic acid and cefazolin groups. Wound infection and urinary tract infection were also higher but not significantly in the ...
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