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Ovarian carcinoma contains endocrine gland-derived growth factor.
2003 MAR 13 - (NewsRx.com & NewsRx.net) -- Ovarian carcinoma contains endocrine gland-derived growth factor.
"The first tissue-specific angiogenic molecule, endocrine gland-derived vascular endothelial growth factor (EG-VEGF), was identified recently in human ovary, raising hopes of developing tumor type-specific angiogenesis inhibitors. In the present study, we analyzed the expression of EG-VEGF mRNA in normal human tissues and ovarian neoplasms by quantitative real-time reverse transcription-PCR," wrote L. Zhang and colleagues, University of Pennsylvania, Center for Research on Reproduction and Women's Health.
"EG-VEGF mRNA was expressed in all ovarian neoplasms examined," researchers reported.
"No significant difference was identified among benign, low malignant potential neoplasms or stage I ovarian cancer, all of which exhibited 2-fold lower mRNA levels compared with normal premenopausal ovaries. EG-VEGF mRNA levels further decreased in late stage compared with early stage carcinomas (p
"EG-VEGF was undetectable by reverse transcription-PCR in 17 established epithelial ovarian cancer cell lines or in cultured human ovarian surface epithelial cells, whereas it was detected in peripheral blood as well as tumor-infiltrating T lymphocytes."
"Finally, in contrast to VEGF, EG-VEGF mRNA levels did not correlate with clinical outcome in advanced ovarian carcinoma. These results suggest ...
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Source: HighBeam Research, Ovarian carcinoma contains endocrine gland-derived growth factor.