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DNA vaccine partially protects murine fetuses from Chlamydophila abortus.
2003 MAR 13 - (NewsRx.com & NewsRx.net) -- DNA immunization with the major outer-membrane protein-encoding gene of Chlamydophila abortus offers partial protection to fetuses of pregnant mice.
"The protective effect of DNA vaccination with the gene encoding the major outer-membrane protein (MOMP) of Chlamydophila abortus has been studied in non-pregnant and pregnant mouse models after chlamydial challenge," researchers in France report.
"OR outbred mice were vaccinated intramuscularly three times every 3 weeks, mated, and challenged with C. abortus 2 weeks after the last injection of DNA," said Celine Hechard and colleagues at the Institut National de la Recherche Agronomique in Nouzilly. "In nonpregnant mice, the MOMP DNA vaccine elicited a specific humoral response with predominantly IgG2a antibodies, suggesting a Th1-type immune response. The induced antibodies showed no in vitro neutralizing effect on C. abortus infectivity. Moreover, immunization with the momp gene showed no reduction in the mean splenic bacterial counts of non-pregnant or pregnant mice or in the mean placental bacterial counts of pregnant mice after the C. abortus challenge. Nevertheless, the MOMP DNA immunization induced a non-specific and partial protection in fetuses against challenge."
The researchers concluded, "Despite the antigenic properties of MOMP, DNA vaccination ...
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Source: HighBeam Research, DNA vaccine partially protects murine fetuses from Chlamydophila...