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High levels of growth factor could be marker for metastatic breast carcinoma.(vascular endothelial growth factor D)
2003 MAR 13 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Scientists have long suspected that growth factors associated with angiogenesis contribute to the spread of certain cancers. A research team in Japan have concluded that at least one marks the metastatic potential of breast carcinoma.
"The angiogenic factor vascular endothelial growth factor D (VEGF-D) is implicated in the development of lymphatic vessels and promotion of lymphatic metastases," explained Yasushi Nakamura and coauthors of Wakayama Medical University, Wakayama City, Japan.
Working with colleagues at Osaka Police Hospital in Osaka, Japan, Nakamura's group stained 105 invasive breast carcinomas for VEGF-D. The samples were acquired from individuals who received long-term follow-up for breast cancer, according to researchers.
More than 80% of the samples expressed VEGF-D, researchers said. There was a positive correlation between VEGF-D expression and cancer in the lymph nodes, and between VEGF-D and elevated expression of c-erbB-2 , an oncogene.
Statistical analysis also showed VEGF-D to be correlated with outcomes such as ...
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Source: HighBeam Research, High levels of growth factor could be marker for metastatic breast...