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2003 MAR 13 - (NewsRx.com & NewsRx.net) -- In confirmation of previous research, and contrary to findings from two recent studies, scientists at the University of California, San Diego (UCSD), School of Medicine have shown that increased levels of estrogen do not correlate with changes in cognitive functioning in postmenopausal women with Alzheimer disease.
The new study, published in the Archives of Neurology, found that elevations in hormone levels did not predict cognitive test scores nor other neuropsychological measures in 120 women with Alzheimer disease who were given various levels of Premarin, a hormone replacement therapy that raises the levels of the hormones estradiol and estrone.
Alzheimer occurs with a higher frequency in women. Although some physicians believed that women with Alzheimer disease who took estrogen experienced improved cognition, three studies in 2000 showed no correlation between estrogen and cognitive improvement. One of those was a multicenter trial published in the Journal of the American Medical Association by the Alzheimer's Disease Cooperative Study, directed by Leon Thal, MD, UCSD professor of neurosciences and a neurologist with the San Diego VA Healthcare System.
Recently, however, two small clinical trials (with 12 and 20 women) had different results. Investigators reported that higher doses of estrogen, delivered in patch form, improved attention and verbal memory in the two ...
Source: HighBeam Research, No correlation in postmenopausal women.(increased estrogen levels...