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Protein from Streptococcus strain G148 induces strong antibody response.
2003 MAR 12 - (NewsRx.com & NewsRx.net) -- B- and T-cell epitopes of BB, a carrier protein derived from the G protein of Streptococcus strain G148 induces a strong antibody response.
According to a study from France, "Most conventional vaccines consist of killed organisms or purified antigenic proteins. Such molecules are generally poorly immunogenic and need to be coupled to carrier proteins. We have identified a new carrier molecule, BB, derived from the G protein of Streptococcus strain G148."
"We show that BB is able to induce strong antibody responses when conjugated to peptides or polysaccharides," said Liliane Goetsch and collaborators at the Centre d'Immunologie Pierre Fabre. "In order to localize T and B cell epitopes in BB and match them with the albumin-binding region of the molecule, we immunized mice with BB, performed B and T pepscan analyses, and compared the results with pepscan done with sera and cells from humans. Our results indicate that BB has two distinct T helper epitopes, seven linear B-cell epitopes, and one conformational B-cell epitope in BALB/c mice. Four linear B-cell epitopes were identified from human sera, three of which overlapped mouse B-cell epitopes. Finally, three human T-cell epitopes were ...
- A human dendritic cell-based method to identify CD[4.sup.+] T-cell epitopes in...
- Magazine article from: Environmental Health Perspectives Stickler, Marcia Mucha, Jeanette Power, Scott Harding, Fiona February 1, 2003 700+ words
...immunodominant CD[4.sup.+] T-cell epitopes in any protein. The method uses CD...food allergens, human donors, T-cell epitopes. Environ Health Perspect 111:251...allele. Interestingly, the same T-cell epitopes are capable of inducing either Th1...
- HLA-DR T cell epitopes of CEA identified colorectal cancer patients.
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...have identified functional HLA-DR T cell epitopes of CEA in patients with colorectal...investigators. "The defined HLA-DR T cell epitopes were spread over the entire CEA molecule...Immunotherapy (Functional HLA-DR T cell epitopes of CEA identified in patients with...
- T- and B-cell epitopes in M. bovis antigen MPB70 induce immune response in mice.
- Newspaper article from: Tuberculosis Week April 14, 2003 700+ words
...amp; NewsRx.net) -- T- and B-cell epitopes in MPB70, a secreted Mycobacterium...tuberculosis." They screened MPB70 "for T-cell epitopes in four different inbred mouse strains...Journal of Immunology (T- and B-cell epitopes in the secreted Mycobacterium bovis...
- EEA1 has many B cell epitopes; neurological disease may occur if at C terminal.
- Newspaper article from: Biotech Week January 21, 2004 700+ words
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- HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.
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...and much has been learned about T cell epitopes recognized by DQ2-restricted T cells...understanding of DQ8-restricted gluten T cell epitopes is more limited, as only 2 epitopes...and DQ8-restricted intestinal T cell epitopes have been defined from T cells that...
- A cell assay identifies all of an antigen's T-cell epitopes in the population.
- Newspaper article from: Gastroenterology Week April 14, 2003 700+ words
...identifies all of an antigen's T-cell epitopes in the population. According to recent...location of immunodominant CD4(+) T-cell epitopes in any protein. The method uses CD4...based method to identify CD4(+) T-cell epitopes in potential protein allergens. Environ...
- Patent No. 7,572,454 Issued on Aug. 11, Assigned to University of Melbourne for...
- News wire article from: US Fed News Service, Including US State News August 18, 2009 700+ words
...Australia, have developed a T helper cell epitopes. The inventors were issued U.S...present invention relates to T helper cell epitopes derived from Canine Distemper Virus...helper cell epitope and optionally B cell epitopes and/or cytotoxic T cells epitopes...
- The H+, K+ ATPase T cell epitopes in humans are similar to the mouse model.
- Newspaper article from: Gastroenterology Week April 14, 2003 700+ words
...NewsRx.com & NewsRx.net) -- The H+, K+ ATPase T cell epitopes in humans are similar to the mouse model. According to a...of Immunology (Characterization of H+,K+-ATPase T cell epitopes in human autoimmune gastritis. Eur J Immunol, 2003;33...