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Association found between class I HLA-B alleles and antibody levels.
2003 MAR 12 - (NewsRx.com & NewsRx.net) -- An association between class IHLA alleles and antibody levels was found after a single dose of measles vaccine.
According to recent research from the United States, "Despite the success of the current measles vaccine in controlling disease in industrialized countries, the importance of vaccine failure has become increasingly apparent. Our objective was to determine if associations exist between seronegativity after measles vaccination and class I human leukocyte antigen (HLA) alleles. We undertook a cross-sectional observational study in Rochester, Minnesota, with 242 school-age children previously recruited from a community-wide seroprevalence study."
"We studied two groups of subjects: 72 were seronegative (EIAless than or equal to0.8 after a single dose of measles vaccine) and 170 were seropositive (enzyme immunoassay [EIA]greater than or equal to1.0 after one dose)," reported Robert M. Jacobson and colleagues at the Mayo Clinic. "We used the resources of Mayo Clinic's tissue typing laboratory for serotyping class I HLA-A and HLA-B alleles via microlymphocytotoxicity assays. We found no statistically significant associations with class I HLA-A but did find ...
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