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Tumor necrosis factor alpha regulates development of Lyme osteoarthritis.
2003 MAR 12 - (NewsRx.com & NewsRx.net) -- Destructive arthritis in vaccinated interferon gamma-deficient mice challenged with Borrelia burgdorferi is modulated by tumor necrosis factor alpha.
"We found that Borrelia burgdorferi-vaccinated gamma interferon-deficient (IFN-gamma[superscript]0) mice challenged with B. burgdorferi developed prominent chronic destructive osteoarthropathy. When these mice were treated with anti-tumor necrosis factor alpha (TNF-alpha) antibody, the severity of the destructive osteoarthritis was enhanced and affected the mobility of the animals," researchers in the United States report.
"In addition, extensive swelling of the hind paws occurred," said John A. Christopherson and colleagues at the University of Wisconsin and Gundersen Lutheran Medical Center. "In contrast, treatment of B. burgdorferi-vaccinated, challenged IFN-gamma[superscript]0 mice with recombinant TNF-alpha (rTNF-alpha) inhibited the development of arthritis, including swelling of the hind paws. Moreover, treatment of vaccinated, challenged IFN-gamma[superscript]0 mice with anti-TNF-alpha inhibited fourfold the production of an antibody that kills B. burgdorferi, while treatment of vaccinated, challenged IFN-gamma[superscript]0 mice with rTNF-alpha slightly elevated the level of the borreliacidal antibody."
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Source: HighBeam Research, Tumor necrosis factor alpha regulates development of Lyme...