AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Vaccine technique shows potential.
2003 MAR 12 - (NewsRx.com & NewsRx.net) -- In a demonstration of vaccine therapy's potential for treating lung cancer, Dana-Farber Cancer Institute scientists and their associates report that a prototype vaccine boosted the natural immune response to tumors in a small group of patients with advanced non-small cell lung cancer (NSCLC). Moreover, the vaccine was found to be nontoxic and well-tolerated.
Findings from the Phase I clinical trial, published in the Journal of Clinical Oncology, will provide an impetus for further efforts to develop a vaccine against NSCLC, a difficult-to-treat condition that accounts for roughly 80% of all lung cancer cases.
"This work represents a new approach to a vaccine for lung cancer patients," said senior author Glenn Dranoff, MD, of Dana-Farber. "We're still at an early stage, but the results of this study are encouraging. They offer a 'proof of principle' that this technique can strengthen the normal immune response to NSCLC tumors and will help form the basis for testing the vaccine in patients with earlier stage lung cancer."
The technique was originally developed for patients with advanced melanoma. The researchers created the melanoma vaccine by removing a portion of a patient's tumor and using specially equipped viruses to insert a gene known as GM-CSF into the tumor cells. After being radiated and injected into the patient, the manipulated tumor cells began producing the granulocyte-macrophage colony-stimulating factor (GM-CSF) protein, which acted as a magnet for an immune system attack on tumor cells. As the researchers had hoped, the vaccine elicited a potent, long-lasting immune response targeted at the melanoma tumor cells and produced only minor side effects.
In the lung cancer study, researchers developed vaccines for 34 of the 35 enrolled patients with metastatic NSCLC. Nine of these patients had to withdraw from the study after ...
- Fluctuation of circulating tumor cells in patients with lung cancer by...
- Magazine article from: Journal of Cancer Research and Therapeutics Mingjian, Ge De, Shi Qingchen, Wu Mei, Wang Liangbin, Li October 1, 2005 700+ words
...the study, we evaluated the CTCs in lung cancer following locoregional radiation therapy...peripheral blood was taken from each lung cancer patients (n=15) both before and...time RT-PCR assay. All patients with lung cancer were treated with primary definitive...
- Lung cancer and fibroblast cocultures reveal genes linked to cancer progression.
- Newspaper article from: Angiogenesis Weekly January 9, 2004 700+ words
...carcinoma in which tumor cells come in contact with...non-small-cell lung cancer tumor cells and normal pulmonary...between epithelial tumor cells and fibroblasts...non-small-cell lung cancer cells reveals alterations...
- Titan Pharmaceuticals Announces Initiation of Phase II Non-Small Cell Lung...
- Press release article from: PR Newswire April 10, 2001 700+ words
...including non-small cell lung cancer, colorectal cancer, pancreatic...including non-small cell lung cancer. These monoclonal antibodies...cancer cells. In non-small cell lung cancer, tumor cells express both CEA and HMFG...
- Lung Cancer Kinase Target Goes Back To ADAM's Time.
- Magazine article from: BIOWORLD Today November 3, 2009 700+ words
...effects of inhibiting ADAMs in lung cancer, but Incyte is furthest along...HER-3 stimulatory loop in lung cancer tumor cells. That loop was related to whether...mutation in HER-2 in certain lung cancer cells. The mutated receptor...
- Research on non-small cell lung cancer genetics described by scientists at...
- Newspaper article from: Cancer Weekly September 8, 2009 700+ words
...advanced non-small-cell lung cancer,' is the subject of a report...see also Non-Small Cell Lung Cancer Genetics). "When tumor cells overexpress both EGFR and...advanced non-small-cell lung cancer (NSCLC). Certain patient...
- GENE QUICKENS LUNG CANCER.(Main)
- Newspaper article from: Albany Times Union (Albany, NY) August 30, 1990 700+ words
Byline: Washington Post Lung cancer patients whose tumor cells contain a certain mutation...disease than are patients whose lung cancer cells do not have the mutation...study by Dutch researchers. Lung cancer is the most common fatal...
- Unique Structure of Geron's Telomerase Inhibitor Drug Promotes Anti-Tumor,...
- Press release article from: Business Wire February 15, 2007 700+ words
...potential of a human lung cancer cell line (A549...in vivo model of lung cancer metastasis in which tumor cells from an intravenous...with A549-luc tumor cells resulted in significant...in vivo model of lung cancer metastasis resulted...
- Cell Genesys Secures Memphis Facility for Manufacturing of Patient-Specific...
- Press release article from: PR Newswire February 12, 2002 700+ words
...for GVAX(R) lung cancer vaccines which...process frozen tumor cells obtained from...GVAX(R) lung cancer vaccine is a patient...II GVAX(R) lung cancer vaccine trial, the patient's own tumor cells were directly...
Source: HighBeam Research, Vaccine technique shows potential.