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Elimination of local macrophages in intestine prevents chronic colitis.
2003 MAR 12 - (NewsRx.com & NewsRx.net) -- Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice.
According to a study from Japan, "Uncontrolled activation of T cells and macrophages is involved in the development of inflammatory bowel disease (IBD). However, the precise role of intestinal macrophages for development of IBD is till unclear. To investigate the role of local macrophages for development of IBD, we developed poly-D,L-lactic acid microspheres containing dichloromethylene diphosphonate, which was specifically taken up by macrophages and depleted them, and then the animal model for human IBD was treated with this reagent."
"We have shown that rectal administration of the microspheres reduced the numbers of resident macrophages in the intestinal lymphoid follicles of interleukin-10-deficient mice," reported Norihiko Watanabe and colleagues at Kyoto University. "Importantly, depletion of intestinal macrophages was associated with suppression of development of chronic colitis."
Watanabe and coauthors concluded, "These results suggest that local macrophages in the intestine play a critical role in the ...
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