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Peptides trap HIV-1 envelope glycoprotein fusion intermediate at two sites.
2003 MAR 12 - (NewsRx.com & NewsRx.net) -- Peptides trap the human immunodeficiency virus type 1 envelope glycoprotein fusion intermediate at two sites.
According to recent research from the United States, "Human immunodeficiency virus type 1 (HIV-1) entry into target cells requires folding of two heptad-repeat regions (N-HR and C-HR) of gp41 into a trimer of N-HR and C-HR hairpins, which brings viral and target cell membranes together to facilitate membrane fusion. Peptides corresponding to the N-HR and C-HR of gp41 are potent inhibitors of HIV infection. Here we report new findings on the mechanism of inhibition of a N-HR peptide and compare these data with inhibition by a C-HR peptide."
"Using intact envelope glycoprotein (Env) under fusogenic conditions, we show that the N-HR peptide preferentially binds receptor-activated Env and that CD4 binding is sufficient for triggering conformational changes that allow the peptide to bind Env, results similar to those seen with the C-HR peptide," said Yong He and collaborators at the Food and Drug Administration. "However, activation by both CD4 and chemokine receptors further enhances Env binding by both ...
- Peptides trap HIV-1 envelope glycoprotein fusion intermediate at two sites.
- Newspaper article from: AIDS Weekly March 10, 2003 700+ words
...mechanism of inhibition of a N-HR peptide and compare these data with inhibition by a C-HR peptide." "Using intact envelope glycoprotein (Env) under fusogenic...conditions, we show that the N-HR peptide preferentially binds receptor...
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...macaque system. The envelope glycoprotein of SIV, gp130, is directly...analogous to the HIV gp120 envelope glycoprotein: both are derived from...macaques vaccinated with SIV envelope glycoprotein-based subunit vaccines...
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...virus genetically engineered to express the SIV gp160 envelope glycoprotein - and then boosted with gp160 produced in cells infected...This recombinant virus expresses the full-length gp120 envelope glycoprotein and a truncated gp32 transmembrane protein in addition...
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...a 94-amino-acid region of the viral gp120 surface envelope glycoprotein, Washington University and Walter Reed Army Institute...to a discrete 94-amino-acid region of the surface envelope glycoprotein, which encompasses the entire V3 loop but contains only...
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- Newspaper article from: AIDS Weekly Buchschacher, G.L. Freed, E.O. Panganiban, A.T. February 27, 1995 700+ words
...that a human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein containing a Val-to-Glu substitution at the second...this position also results in a dominant interfering envelope glycoprotein." The corresponding author for this study is: AT Panganiban...
- Calcium ions and human cell components are required for cell fusion mediated by...
- Newspaper article from: AIDS Weekly Dimitrov, D.S. Broder, C.C. Berger, E.A. Blumenthal, R. August 30, 1993 700+ words
...mediated by interactions between CD4 and the HIV-1 envelope glycoprotein (gp120-gp41), we used cells, expressing gp120...essential for cell fusion mediated by the CD4-HIV-1 envelope glycoprotein interaction."
- Human immunodeficiency virus type 2 envelope glycoprotein: differential CD4...
- Newspaper article from: AIDS Weekly Mulligan, M.J. Ritter, G.D., Jr. Chaikin, M.A. Yamshchikov, G.V. Hahn, B.H. Sweet, R.W. Compans, R.W. February 3, 1992 700+ words
...affinity for both. From these experiments, we conclude that relevant biological properties of the HIV-2 envelope glycoprotein - e.g., receptor binding, cytopathic potential, and susceptibility to sCD4 inhibition - are reflected...
- Analysis of mutations in the HIV-1 envelope glycoprotein that affect fusion and...
- Newspaper article from: AIDS Weekly Page, K.A. Stearns, S.M. Littman, D.R. August 19, 1991 700+ words
...A conserved sequence of amino acids is centered in the third hypervariable (V3) region of the HIV-1 envelope glycoprotein gp160. It is likely that this region of gp160 mediates post-binding virus entry events. Mutations were introduced...
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- Newspaper article from: AIDS Weekly Jones, D.H. Mcbride, B.W. Roff, M.A. Maloney, V. Farrar, G.H. April 4, 1994 700+ words
...an article published in Vaccine, "A non-denaturing method has been developed for the purification of the envelope glycoprotein gp130 of the simian immunodeficiency virus (SIV) using infected cells as starting material. The procedure...
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- Newspaper article from: AIDS Weekly Dimitrov, D.S. Hillman, K. Manischewitz, J. Blumenthal, R. Golding, H. March 23, 1992 700+ words
...Society, held in Houston, Texas, February 9-13, 1992, "The high -affinity interaction between the HIV-1 envelope glycoprotein and its receptor, CD4, is required for viral entry into cells. We studied the kinetics of binding of the...
Source: HighBeam Research, Peptides trap HIV-1 envelope glycoprotein fusion intermediate at two...