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Intra-tumoral injection of CpG inhibits tumor growth in murine colon tumors.
2003 MAR 12 - (NewsRx.com & NewsRx.net) -- Intra-tumoral injection of CpG results in the inhibition of tumor growth in murine colon-26 and B-16 tumors.
"Direct tumor injections of CpG (ODN #1826) into murine tumors markedly suppressed the tumor growth and increased the survival of the mice. Tumor growth was reduced by 60-67% in Colon Tumor 26 (CT-26) and B-16 melanoma tumors treated with CpG as compared to untreated one. In CT-26 and B-16 tumors treated with CpG, the average survival of the animals were prolonged to 26 and 28 days as compared to 16 and 18 days in controls, respectively," researchers in the United States report.
"Long-term surviving animals in CT-26 tumor groups were also protected from a subsequent injection of a lethal dose of tumor cells," said Sanjay Sharma and colleagues at the State University of New York at Buffalo and CCS Oncology. "In the present study, effect of CpG was mediated through CD8+ T cells, as their depletion resulted in the abrogation of the therapeutic effects of ...
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Source: HighBeam Research, Intra-tumoral injection of CpG inhibits tumor growth in murine colon...