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Meningitis risk after measles-mumps-rubella vaccination varies by vaccine strain.

Vaccine Weekly

| March 12, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 MAR 12 - (NewsRx.com & NewsRx.net) -- A case-crossover design has revealed that the risk of meningitis after measles-mumps-rubella vaccination varies by vaccine strain.

According to recent research from Korea, "Epidemiologic study of a vaccine's adverse events is not easy; so many countries have no reliable data. Vaccines containing the Urabe or Hoshino strain have been withdrawn from use in several countries. However, the data are not strong enough to form the basis of a recommendation not to use specific strains."

Moran Ki and colleagues at Eulji University School of Medicine, Seoul National University, and Hanyang University College of Medicine report the use of a "case-crossover design to estimate the relative risk of aseptic meningitis in children after receiving the measles-mumps-rubella vaccine in Korea. Study subjects were hospitalized children aged 8-36 months who had aseptic meningitis in 1998. Cases were confirmed by hospital chart reviews using previously defined criteria. Through a telephone survey, the authors obtained vaccination date and place information from parents' vaccination records."

"Study results showed that no significant risk was associated with the Jeryl Lynn or Rubini strain of the vaccine (relative risk=0.6, ...

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