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Advances in therapeutic vaccines for neurodegenerative disorders outlined.

Vaccine Weekly

| March 12, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 MAR 12 - (NewsRx.com & NewsRx.net) -- Research into the development of therapeutic vaccines for neurodegenerative disorders may provide new treatment options.

"Insults to the central nervous system (CNS), whether of microbial or microbe-free origin, result in tissue damage. Until recently, it was generally believed that only microbe-related damage elicits an adaptive immune response, the purpose of which is to eliminate the offending microorganisms. Recent studies in the author's laboratory suggest, however, that the body exhibits an adaptive immune response to microbe-free injuries as well," a researcher in Israel reports.

"The immune response in this case is directed against dominant self-antigens residing in the damaged site, where such an adaptive anti-self immune response reinforces the protective activity of local resident cells by providing them with factors that can augment and regulate their capacity for buffering troublemakers such as destructive self-compounds emerging from the injured neural tissue," said Michal Schwartz at the Weizmann Institute of Science in Rehovot. "Because the specificity of this ...

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Source: HighBeam Research, Advances in therapeutic vaccines for neurodegenerative disorders...

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