AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
DNA vaccine partially protects murine fetuses from Chlamydophila abortus.
2003 MAR 12 - (NewsRx.com & NewsRx.net) -- DNA immunization with the major outer-membrane protein-encoding gene of Chlamydophila abortus offers partial protection to fetuses of pregnant mice.
"The protective effect of DNA vaccination with the gene encoding the major outer-membrane protein (MOMP) of Chlamydophila abortus has been studied in non-pregnant and pregnant mouse models after chlamydial challenge," researchers in France report.
"OR outbred mice were vaccinated intramuscularly three times every 3 weeks, mated, and challenged with C. abortus 2 weeks after the last injection of DNA," said Celine Hechard and colleagues at the Institut National de la Recherche Agronomique in Nouzilly. "In nonpregnant mice, the MOMP DNA vaccine elicited a specific humoral response with predominantly IgG2a antibodies, suggesting a Th1-type immune response. The induced antibodies showed no in vitro neutralizing effect on C. abortus infectivity. Moreover, immunization with the momp gene showed no reduction in the mean splenic bacterial counts of non-pregnant or pregnant mice or in the mean placental bacterial counts of pregnant mice after the C. abortus challenge. Nevertheless, the MOMP DNA immunization induced a non-specific and partial protection in fetuses against challenge."
The researchers concluded, "Despite the antigenic properties of MOMP, DNA ...
- DNA vaccine partially protects murine fetuses from Chlamydophila abortus.
- Newspaper article from: OBGYN & Reproduction Week March 10, 2003 700+ words
...encoding gene of Chlamydophila abortus offers partial...fetuses of pregnant mice. "The protective...MOMP) of Chlamydophila abortus has been...protection against Chlamydophila abortus challenge...and non-pregnant mice. J Med Microbiol...
- Chlamydophila abortus pelvic inflammatory disease.(Dispatches)
- Magazine article from: Emerging Infectious Diseases Walder, Gernot Meusburger, Herwig Hotzel, Helmut Oehme, Albrecht Neunteufel, Walter Dierich, Manfred P. Wurzner, Reinhard December 1, 2003 700+ words
We report the first documented case of an extragestational infection with Chlamydophila abortus in humans. The pathogen was identified in a patient with severe pelvic inflammatory disease (PID) by sequence analysis of the...
- Pregnant mice block out unwelcome admirers to protect their pups.
- Magazine article from: Women's Health Weekly August 7, 2008 700+ words
...can cause miscarriage and reactivate the ovulatory cycle, pregnant mice prevent the action of such olfactory stimuli by blocking...discrimination of social odours contained in male urine. Treating pregnant mice with chemicals that block the dopamine receptor D2 abolished...
- Bisphenol a exposure in pregnant mice permanently changes DNA of offspring.
- Magazine article from: Women's Health Weekly June 25, 2009 700+ words
...at Yale University School of Medicine. To find the answer to that question, Taylor and his co-workers at Yale injected pregnant mice with a low dose of BPA on pregnancy days 9 to 16. After the mice gave birth, the scientists analyzed the uterus of female...
- Amelioration of zidovudine-induced fetal toxicity in pregnant mice. (Periodical...
- Newspaper article from: AIDS Weekly December 14, 1992 700+ words
...effects of AZT on fetal mice as measured by number of fetuses, fetal size and the fetal hepatic cell clonogenic assay. When pregnant mice received AZT via drinking water from days 1 to 13 of gestation, Gogu et al. noticed dose-dependent toxic effects...
- Mice on Mars. (News in Brief).(Pregnant mice to be sent into space)(Brief...
- Magazine article from: Chemistry and Industry October 1, 2002 700+ words
Scientists are planning to send pregnant mice into space, to determine whether mammals can reproduce safely in space, and inhabit planets such as Mars. Up to 12 mice will...
- ELF magnetic fields cause no adverse effects in pregnant mice or offspring.
- Newspaper article from: Medical Devices & Surgical Technology Week July 25, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Extremely low frequency (ELF) magnetic fields do not cause negative effects in pregnant mice, their fetuses, or their offspring, researchers report. According to M.K. Chung and colleagues at the Korea Institute...
- Stopping cellular traffic in pregnancy.(cell-death-inducing Fas ligand found in...
- Magazine article from: Science News Travis, John June 14, 1997 700+ words
...death-inducing Fas ligand (FasL) has also emerged in another arena. Cells in the uterus and placenta of pregnant mice make FasL, report Joan S. Hunt of the University of Kansas Medical Center in Kansas City and her colleagues in...
- Parachlamydia spp. and related Chlamydia-like organisms and bovine...
- Magazine article from: Emerging Infectious Diseases Borel, Nicole Ruhl, Silke Casson, Nicola Kaiser, Carmen Pospischil, Andreas Greub, Gilbert December 1, 2007 700+ words
Chlamydophila abortus and Waddlia chondrophila cause abortion in ruminants. We investigated the role of Parachlamydia acanthamoebae in bovine abortion...
- Parachlamydia acanthamoebae infection and abortion in small...
- Magazine article from: Emerging Infectious Diseases Ruhl, Silke Goy, Genevieve Casson, Nicola Thoma, Rudolf Pospischil, Andreas Greub, Gilbert Borel, Nicole December 1, 2008 700+ words
...several abortigenic agents have a zoonotic potential, i.e., Brucella abortus, Coxiella burnetii, and Chlamydophila abortus. C. abortus, which causes ovine enzootic abortion, may also infect pregnant women who have had contact with...
Source: HighBeam Research, DNA vaccine partially protects murine fetuses from Chlamydophila...