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Complement component 3 required for expansion of CD8 cells in viral infections.
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "In addition to its established role in innate immune mechanisms, complement component C3 is also of critical importance in B cell activation and T cell-dependent antibody responses. In this study, we have examined the requirement for C3 in the generation of primary CD8 T cell responses to an acute systemic viral infection."
"We compared antigen-specific CD8 T cell responses to lymphocytic choriomeningitis virus (LCMV) between wild-type (+/+) and C3-deficient (C3-/-) mice on both 129/B6 and B6 backgrounds," stated M. Suresh and colleagues at the Universities of Wisconsin, Maryland, and Pennsylvania. "These studies revealed that C3 activity is required for optimal expansion of LCMV-specific effector CD8 T cells in an epitope-dependent fashion, which is influenced by the genetic background of the mice. Studies in complement receptor 1/2 (CR1/CR2)-deficient mice showed that regulation of LCMV-specific CD8 T cell responses by C3 is not dependent upon CR1/CR2."
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Source: HighBeam Research, Complement component 3 required for expansion of CD8 cells in viral...