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Cholera toxin induces migration of dendritic cells.(Brief Article)
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Intestinal M cells deliver macromolecules, particles, and pathogens into the subepithelial dome (SED) region of Peyer's patch mucosa, an area rich in dendritic cells (DCs). We tested whether uptake of the mucosal adjuvant cholera toxin (CT) or live Salmonella bacteria can induce DC migration within Peyer's patches."
"Virus-sized, fluorescent polystyrene microparticles were efficiently transported by M cells and ingested by CD11c+, CD11b-, and CD8a- DCs in the SED region," reported Vijay K. Shreedhar and colleagues at Harvard Medical School and the National Institutes of Health. "DCs loaded with microparticles remained in the SED for up to 14 days. CT (but not the CT B subunit) and live attenuated Salmonella enterica serovar Typhimurium bacteria induced migration of the microparticle-loaded DCs from the SED region into underlying B-cell follicles and adjacent parafollicular T-cell zones."
The researchers ...
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