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Antigen 85A expression enhances immunogenicity to Mycobacterium tuberculosis.(Brief Article)

Vaccine Weekly

| March 05, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "The immunogenicity of a plasmid DNA vaccine incorporating Sindbis virus RNA replicase functions (pSINCP) and expressing antigen 85A (Ag85A) from Mycobacterium tuberculosis was compared with a conventional plasmid DNA vector encoding Ag85A."

"pSINCP-85A was highly immunogenic in mice and gave enhanced long-term protection against M. tuberculosis compared with the conventional vector," reported Joanna R. Kirman and her colleagues at the National Institutes of Health, the Food and Drug Administration, and Chiron Corporation.

Kirman and her coauthors published the results of their study in Infection and Immunity (Enhanced immunogenicity to Mycobacterium tuberculosis by vaccination with an alphavirus plasmid replicon ...

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