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DNA vaccine primes CD8+ T cells to control Toxoplasma gondii infection.
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Belgium, "Protective immunity against Toxoplasma gondii is known to be mediated mainly by T lymphocytes and gamma interferon (IFN-gamma). The contribution of CD4+ and CD8+ T-lymphocyte subsets to protective immune responses against T. gondii infection, triggered by a GRA1 (p24) DNA vaccine, was assessed in this study."
"In vitro T-cell depletion experiments indicated that both CD4+ and CD8+ T-cell subsets produced IFN-gamma upon restimulation with a T. gondii lysate," reported T. Scorza and collaborators at the Pasteur Institute of Brussels. "In addition, the GRA1 DNA vaccine elicited CD8+ T cells that were shown to have cytolytic activity against parasite-infected target cells and a GRA1-transfected cell line. C3H mice immunized with the GRAI DNA vaccine showed 75 to 100% protection, while 0 to 25% of the mice immunized with the empty control vector survived challenge with T. gondii cysts. In vivo T-cell depletion experiments indicated that CD8+ T cells were essential for the ...
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- Newspaper article from: TB & Outbreaks Week February 18, 2003 700+ words
...describe pituitary adenoma in association with Toxoplasma gondii infection. The two patients were 43- and 19-year-old women...reports of pituitary adenoma associated with Toxoplasma gondii infection. J Clin Pathol, 2002;55(12):965-966). The...
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- Magazine article from: Journal of the Alabama Academy of Science April 1, 2009 700+ words
TOXOPLASMA GONDII INFECTION RATES IN FERAL HOUSE CATS (FELIS CATUS) IN SUMTER COUNTY, ALABAMA. Domoneek McCoy, Tracy Duckworth, Department of Biological...
- Toxoplasma gondii infection in the United States, 1999-2000.(Synopses)
- Magazine article from: Emerging Infectious Diseases Jones, Jeffrey L. Kruszon-Moran, Deanna Wilson, Marianna November 1, 2003 700+ words
...for life. When a pregnant woman is infected for the first time, and the infection spreads to the fetus, congenital T. gondii infection may be clinically apparent in the neonate in the first months of life or later during infancy, childhood, or adolescence...
- Recently acquired Toxoplasma gondii infection, Brazil.
- Magazine article from: Emerging Infectious Diseases Jones, Jeffrey L. Muccioli, Cristina Belfort, Rubens, Jr. Holland, Gary N. Roberts, Jacquelin M. Silveira, Claudio April 1, 2006 700+ words
...risk factors for acute T. gondii infection in this area, we administered...increased risk for T. gondii infection in univariate analysis...associated with acute T. gondii infection in multivariate analysis...
- Therapeutic HER2/Neu DNA vaccine blocks the growth of murine tumors.
- Newspaper article from: Obesity, Fitness & Wellness Week December 4, 2004 700+ words
...NewsRx.net) -- Therapeutic HER2/Neu DNA vaccine blocks the growth of murine tumors...therapeutic model, N'-neu-IL-2 DNA vaccine was significantly better than N'-neu DNA vaccine, and N'-neu DNA vaccine was significantly...
