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Tolerance to bacterial lipoprotein enhances survival to many challenges.
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from Ireland, "Tolerance to bacterial cell wall components is an adaptive host response. Endotoxin/LPS tolerance is characterized by a survival advantage against subsequent lethal LPS challenge. However, it is uncertain whether LPS tolerance can afford protection against other septic challenges.
"In this study, we show that tolerance induced by bacterial lipoprotein (BLP) protects mice against not only BLP-induced lethality, but also LPS, live bacterial, and polymicrobial sepsis-induced lethality. In contrast, LPS tolerance offers no survival benefit against the latter two challenges," stated J.H. Wang and coauthors, National of University of Ireland, Cork University Hospital.
Wang and coauthors concluded: "Furthermore, induction of BLP tolerance results in overexpression of complement receptor type 3 and FcgammaIII/IIR on neutrophils (polymorphonuclear neutrophils) and peritoneal macrophages, with increased bacterial recognition and bactericidal activity, whereas ...
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Source: HighBeam Research, Tolerance to bacterial lipoprotein enhances survival to many...