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Feasibility of an HA2 domain-based periodontitis vaccine.(Brief Article)

Vaccine Weekly

| March 05, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease," researchers in the United States and Australia report.

"Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies," stated A. A. DeCarlo and associates at Agenta Biotechnologies in Alabama, the University of Alabama at Birmingham, and the University of Sydney in Australia. "The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline."

DeCarlo and colleagues published their study in Infection and ...

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