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Protective efficacy of the RTS,S/AS02 malaria vaccine is not strain specific.
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from England, "RTS,S/AS02 is a recombinant protein malaria vaccine that contains a large portion of the C-terminal of the circumsporozoite protein (CSP) sequence of the NF54 isolate of Plasmodium falciparum fused to the hepatitis B virus surface antigen. It has been shown to induce significant protection to challenge infection with a homologous parasite strain in American volunteers."
"In a recently completed trial in semi-immune Gambian adults, vaccine efficacy against natural infection was 34% (95% confidence interval=8-53%, p=0.014) during the malaria season following vaccination," reported Ali Alloueche and colleagues at the London School of Hygiene and Tropical Medicine. "Breakthrough P. falciparum parasites sampled from vaccinated subjects and from controls were genotyped at two polymorphic regions of the csp gene encoding T cell epitopes (csp-th2r and csp-th3r) to determine if the vaccine conferred a strain-specific effect."
The researchers concluded, "The overall distribution of csp allelic variants was ...
- New malaria vaccine shows some promise.
- Magazine article from: Insight on the News Kaberia, Kirimi December 12, 1994 700+ words
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...Journal of Tropical Medicine and Hygiene...S+TRAP malaria vaccine, formulated...Society for Tropical Medicine and Hygiene...subject areas of Malaria Vaccine, Vaccine...Pediatrics, and Tropical Medicine. This article...
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...study in Lancet (Malaria vaccine developments. Lancet...Vasee S. Moorthy, Malaria Vaccine Initiat, 6290 Montrose...subject areas of Malaria Vaccine, Mosquito-Borne...Immunotherapy, Tropical Medicine, and Vectors and...
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...Plasmodium falciparum malaria vaccine candidate merozoite...Plasmodium falciparum malaria vaccine candidate merozoite...subject areas of Malaria Vaccine, Vaccine Development...Parasitology, Tropical Medicine, and Proteomics...
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- Newspaper article from: Vaccine Weekly May 18, 1998 700+ words
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- Protective efficacy of the RTS,S/AS02 malaria vaccine is not strain...
- Newspaper article from: Medical Letter on the CDC & FDA March 9, 2003 700+ words
...Journal of Tropical Medicine and Hygiene...falciparum malaria vaccine is not strain...Hygiene and Tropical Medicine, London...Society for Tropical Medicine and Hygiene...subject areas of Malaria Vaccine, Malaria...
- Cellular immunity induced by malaria vaccine, RTS,S/AS02, in adults in Gambia.
- Newspaper article from: Health & Medicine Week March 22, 2004 700+ words
...Plasmodium falciparum malaria vaccine, RTS,S/AS02...Plasmodium falciparum malaria vaccine, RTS,S/AS02...subject areas of Malaria Vaccine, Malaria Therapy...Borne Disease, Tropical Medicine, and Vectors and...