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Antibody subclasses in malaria-immune individuals improve vaccine design.
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from France, Senegal, and the United States, "Immunity against the blood stage of Plasmodium falciparum malaria is associated with protective-type antibodies of certain classes and subclasses. Field studies have demonstrated the differential regulation of various IgG subclasses depending on the dynamics of parasite transmission and on the immune status of the individuals tested."
"The intrinsic properties of each IgG subclass has a crucial role in protection, both because immunoglobulin levels are dependent on their production and clearance from blood and because antibodies are actively used for parasite clearance," stated Olivier Garraud at the Universite Jean Monnet in Etienne, France and colleagues at the Institut Pasteur de Dakar in Dakar, Senegal and the Centers for Disease Control and Prevention in the United States. "In vitro models using B cells obtained from P. falciparum-immune adults have enabled study of the production of various antibody subclasses depending on the individual and on the antigens used."
Garraud and coauthors concluded, "Ex vivo and in vitro observations from ...
- Antibody subclasses in malaria-immune individuals improve vaccine design.
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...parasite clearance," stated Olivier Garraud at the Universite Jean Monnet...of the production of various antibody subclasses depending on the individual...corresponding author for this report is Olivier Garraud, Groupe Immunite des Muqueuses...
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Source: HighBeam Research, Antibody subclasses in malaria-immune individuals improve vaccine...