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Genetically modified H5N1 influenza A virus vaccine candidate developed.
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States and England, "Avian influenza A H5N1 viruses similar to those that infected humans in Hong Kong in 1997 continue to circulate in waterfowl and have reemerged in poultry in the region, raising concerns that these viruses could reappear in humans. The currently licensed trivalent inactivated influenza vaccines contain hemagglutinin (HA) and neuraminidase genes from epidemic strains in a background of internal genes derived from the vaccine donor strain, A/Puerto Rico/8/34 (PR8). Such reassortant candidate vaccine viruses are currently not licensed for the prevention of human infections by H5N1 influenza viruses."
"A transfectant H5N1/PR8 virus was generated by plasmid-based reverse genetics," reported Kanta Subbarao and collaborators at the U.S. Centers for Disease Control and Prevention, the U. S. Department of Agriculture, and Oxford University. "The removal of the multibasic amino acid motif in the HA gene associated with high pathogenicity in chickens, and the new genotype of the H5N1/PR8 transfectant virus, attenuated the virus for chickens and mice without altering the antigenicity of the HA. A formalin-inactivated vaccine prepared from ...
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- Genetically modified H5N1 influenza A virus vaccine candidate developed.(Brief...
- Newspaper article from: Medical Letter on the CDC & FDA March 9, 2003 700+ words
...S. Centers for Disease Control and Prevention, the...reassortant H5N1 influenza A virus vaccine candidate generated...Branch, Centers for Disease Control and Prevention, Mailstop...areas of Influenza Virus Vaccine and Vaccine Development...
Source: HighBeam Research, Genetically modified H5N1 influenza A virus vaccine candidate...