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Toll-like receptors act as sensors in immune surveillance.(Brief Article)
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Natural IFN-alpha/beta producing cells (IPCs) play a central role in innate immunity against microbial infections. In primary immune responses, toll-like receptors (TLRs), as major pattern-recognition receptors, are essential for IPCs as well as other antigen presenting cell (APC) subsets to recognize microbes."
"IPCs unequivocally express TLR7 and TLR9, and can respond to the respective ligand to produce IFN-alpha/beta and to rapidly differentiate into dendritic cells (DCs)," reported Tomoki Ito and collaborators at Kansai Medical University in Osaka. "Thereby, IPCs can not only activate innate immune system but also provoke T cell responses. Thus, IPCs link innate and adaptive immunity through TLR system. In addition, recent work has revealed the regulatory system of DC subsets in response to microbial invasion."
Ito and coauthors concluded, "In this context, by the different but complementary expression profile of TLRs, IPCs ...
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Source: HighBeam Research, Toll-like receptors act as sensors in immune surveillance.(Brief...