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Epidermal powder immunization a safe and effective vaccination method.
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers at PowderJet Vaccines, Inc., have announced that hepatitis B virus (HBV) antigen can be delivered as a powdered formulation to the skin and generate an effective immune system response.
"We have previously shown that epidermal powder immunization with a powdered inactivated influenza virus vaccine, by targeting the Langerhans cell-rich epidermis, was more efficacious than deeper tissue injection using a needle and syringe," said Jorge E. Osorio and colleagues of PowderJet Vaccines, Inc., which is located in Madison, Wisconsin.
According to Osorio's group, epidermal power immunization with HBV surface antigen (HBsAg), even when unconjugated with adjuvant, yielded a strong humoral and cellular response comparable to that of needle and syringe administration into the muscle.
When conjugated with CpG oligonucleotides, HBV epidermal power immunization was even more effective, researchers said. Antibody response, T helper cell activity, and cytokine secretion increased as a result of oligonucleotide conjugation (Immune responses to hepatitis B surface ...
- Epidermal powder immunization a safe and effective vaccination method.
- Newspaper article from: Biotech Week March 5, 2003 700+ words
...Researchers at PowderJet Vaccines, Inc...shown that epidermal powder immunization...colleagues of PowderJet Vaccines, Inc...Osorio, PowderJet Vaccines, Inc...include: * Epidermal powder administration...
- Epidermal powder immunization enhances vaccine immunogenicity.
- Newspaper article from: Obesity, Fitness & Wellness Week August 21, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Epidermal powder immunization enhances vaccine immunogenicity...research from the United States, "Epidermal powder immunization (EPI) of mice with...published their study in Virus Research (Epidermal powder immunization: cellular and molecular...
- Epidermal Powder Immunization Confers Protection With Or Without Adjuvants.
- Newspaper article from: Biotech Week August 22, 2001 700+ words
...Influenza vaccine delivered via epidermal powder immunization (EPI) can offer protection...influenza virus vaccine induced by epidermal powder immunization," J Virol, September...primarily circulating antibodies * Epidermal powder immunization elicited both serum antibody...
- Epidermal Powder Immunization Confers Protection With Or Without...
- Newspaper article from: Vaccine Weekly August 22, 2001 700+ words
...Influenza vaccine delivered via epidermal powder immunization (EPI) can offer protection...influenza virus vaccine induced by epidermal powder immunization," J Virol, September...primarily circulating antibodies * Epidermal powder immunization elicited both serum antibody...
- Adjuvants Improve Potency Of Epidermal Powder Immunization.
- Newspaper article from: Immunotherapy Weekly May 9, 2001 700+ words
...net) -- by N.R. Saltmarsh, staff medical writer - Epidermal powder immunization (EPI) is an attractive delivery route for...DNA led to a Th-1 type of response ("Adjuvantation of epidermal powder immunization, Vaccine, April 6, 2001;19(20-22...
- Adjuvants Improve Potency Of Epidermal Powder Immunization.(against influenza)
- Newspaper article from: Biotech Week May 9, 2001 700+ words
...Network) -- by N.R. Saltmarsh, staff medical writer - Epidermal powder immunization (EPI) is an attractive delivery route for...DNA led to a Th-1 type of response ("Adjuvantation of epidermal powder immunization, Vaccine, April 6, 2001;19(20-22...
- Adjuvants Improve Potency Of Epidermal Powder Immunization.(Brief Article)
- Newspaper article from: Vaccine Weekly May 9, 2001 700+ words
...net) -- by N.R. Saltmarsh, staff medical writer - Epidermal powder immunization (EPI) is an attractive delivery route for...DNA led to a Th-1 type of response ("Adjuvantation of epidermal powder immunization, Vaccine, April 6, 2001;19(20-22...
- Gold Powder Might Replace Needle-Sticks In The Future.
- Newspaper article from: Hepatitis Weekly January 7, 2002 700+ words
...using the method, which they call epidermal powder immunization (EPI), to vaccinate...also induced after EPI immunization (Epidermal powder immunization induces both cytotoxic...reported in this study include: * Epidermal powder immunization (EPI) is accomplished...
