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Whole HIV-1 protein in liposomes prime CD8+ cells.(Brief Article)
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "Proteins may serve as ideal CD8+ T cell immunogens for human immunodeficiency virus type 1 (HIV-1) if they can be delivered to and processed through the human leukocyte antigen class I pathway," researchers in the United States report.
"This study shows that human blood monocyte-derived dendritic cells loaded with liposome-complexed HIV-1 proteins and matured with CD40 ligand can prime CD8+ T cells to HIV-1 in vitro," reported Xiao-Li Huang and colleagues at the University of Pittsburgh and Immunex Corporation. "Whole HIV-1 protein in liposome may be an effective immunogen for HIV-1 vaccine protocols."
Huang and associates published their study in the Journal of Infectious Diseases (Priming of ...
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Source: HighBeam Research, Whole HIV-1 protein in liposomes prime CD8+ cells.(Brief Article)