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IL-2 increases CD4+ numbers but does not enhance responses to immunization.(Brief Article)
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "To ascertain whether CD4+ lymphocyte increases induced by interleukin (IL)-2 enhanced in vivo immune responses, 38 human immunodeficiency virus (HIV)-infected patients who had received highly active antiretroviral therapy (HAART) or HAART and IL-2 for at least 60 weeks were immunized with tetanus toxoid, inactivated glycoprotein 120-depleted HIV-1, and hepatitis A and B vaccines."
"Despite dramatic increases in CD4+ lymphocyte counts, IL-2 did not enhance immunization responses," reported Hernan Valdez at University Hospitals of Cleveland and colleagues throughout the United States.
Valdez and associates published their study in the Journal of Infectious Diseases (Interleukin-2 increases CD4(+) lymphocyte ...
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