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Therapeutic dendritic-cell vaccine effective against simian AIDS.
2003 MAR 5 - (NewsRx.com & NewsRx.net) -- "An effective immune response against human immunodeficiency virus or simian immunodeficiency virus (SIV) is critical in achieving control of viral replication. Here, we show in SIV-infected rhesus monkeys that an effective and durable SIV-specific cellular and humoral immunity is elicited by a vaccination with chemically inactivated SIV-pulsed dendritic cells," researchers in France and China report.
"After three immunizations made at two-week intervals, the animals exhibited a 50-fold decrease of SIV DNA and a 1,000-fold decrease of SIV RNA in peripheral blood," stated Wei Lu and collaborators at the Institut de Recherche sur les Vaccins et l'Immunotherapie des Cancers et du Sida in Paris and the Tropical Medicine Institute in Guangzhou. "Such reduced viral load levels were maintained over the remaining 34 weeks of the study. Molecular and cellular analyses of axillary and inguinal node lymphocytes of vaccinated monkeys revealed a correlation between decreased SIV DNA and RNA levels and increased SIV-specific T-cell responses. ...
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- Press release article from: Business Wire September 3, 2009 700+ words
Preclinical Study Shows Decrease in Virus Spread in Bloodstream of Animals with HIV-Like Infection SAN DIEGO -- Inovio Biomedical Corporation (NYSE Amex:INO), a leader in DNA vaccine design, development and delivery, announced today that data generated from a pre-clinical collaborative study by
- Therapeutic dendritic-cell vaccine effective against simian AIDS.(Brief Article)
- Newspaper article from: AIDS Weekly March 3, 2003 700+ words
...50-fold decrease of SIV DNA and a 1,000-fold...correlation between decreased SIV DNA and RNA levels and increased...Therapeutic dendritic-cell vaccine for simian AIDS. Nat...HIV Therapy, Dendritic Cell Vaccine, Immunotherapy, and...
- Therapeutic dendritic-cell vaccine effective against simian AIDS.
- Newspaper article from: AIDS Vaccine Week March 3, 2003 700+ words
...50-fold decrease of SIV DNA and a 1,000-fold...correlation between decreased SIV DNA and RNA levels and increased...Therapeutic dendritic-cell vaccine for simian AIDS. Nat...HIV Therapy, Dendritic Cell Vaccine, Immunotherapy, and...
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- Press release article from: PR Newswire December 11, 2003 700+ words
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