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Estrogen receptors interact with the Fas ligand promoter in human monocytes.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "The predominance of autoimmume diseases among women suggests that estrogen may modulate immune function.
"Monocytes and macrophages are important in initiating, maintaining, and resolving inflammatory responses through cell-signaling molecules, which control immune cell survival. One important mechanism of cell survival is mediated by the Fas/ras ligand (FasL) system," stated G. Mor and coauthors, Yale University School of Medicine.
"In this study, the link between estrogen, monocytes/macrophages, and the Fas/FasL system was investigated. Estrogen treatment increased FasL expression in monocytes through the binding of the estrogen receptors (ER) to the estrogen recognizing elements and AP-1 motifs present at the FasL promoter. Furthermore, estrogen induced apoptosis in monocytes expressing ERbeta, but not in monocyte-differentiated macrophages expressing ERalpha.
"The expression of either ERalpha or ERbeta and their response to estrogen in monocytes was found to be dependent on their stage of cell differentiation. Previously, we have shown that estrogen replacement therapy in postmenopausal women decreased the number of circulating monocytes. In this study, we have characterized the molecular mechanism by which estrogen ...
- Researchers from Yale University report on findings in enzyme research.
- Newspaper article from: Biotech Week November 12, 2008 700+ words
...membrane-bound estrogen receptors (ERs)," scientists...and colleagues, Yale University. The researchers...membrane-bound estrogen receptors. Journal of Neuroscience...K.M. Frick, Yale University, Dept. of Psychology...
- Scientists identify molecular link between estrogen receptors and metastasis.
- Newspaper article from: Cancer Weekly May 13, 2003 700+ words
...scientists have discovered a link between estrogen receptors - the molecules that bind the estrogen...drugs that are aimed at blocking estrogen receptors. The research is published in Cell...Geigerman, and Carlos S. Moreno, PhD. Estrogen receptors regulate normal breast cell growth...
- Blocking breast cancer: do faulty estrogen receptors make a meaner, tougher...
- Magazine article from: Science News Fackelmann, Kathy A. May 12, 1990 700+ words
...breast cancer than tumors without estrogen receptors. Furthermore, women with estrogen...chemotherapy. Yet the presence of estrogen receptors in a breast tumor may, in fact...New research suggests that the estrogen receptors in some breast tumors are defective...
- Estrogen receptors detected in bone cells.
- Magazine article from: Science News Hendricks, Melissa July 2, 1988 700+ words
Estrogen receptors detected in bone cells For years...of bone, they have looed for estrogen receptors within bone cells, but to no...have spotted several thousand estrogen receptors per cell. But with improved techniques...
- The raloxifene analog LY117018 entices estrogen receptors to regenerate nerves.
- Newspaper article from: Drug Week September 26, 2003 700+ words
...raloxifene analog LY117018 entices estrogen receptors to regenerate nerves. "The aim...effects of LY117018, delineating estrogen receptors as its target. Our study suggests...functional recovery through activation of estrogen receptors," said McMurray and coauthors...
- Group Studies Estrogen Receptors And Cancer Prevention In Chronic Hepatitis C.
- Newspaper article from: Hepatitis Weekly November 5, 2001 700+ words
...HCV). Medical researchers in Japan have confirmed that estrogen receptors (ERs) on the liver, which modulate estrogen activity...several risk factors for HCV-related liver cancer * Estrogen receptors on the liver may prevent patients with chronic hepatitis...
- Group Studies Estrogen Receptors And Cancer Prevention In Chronic Hepatitis...
- Newspaper article from: Cancer Weekly November 6, 2001 700+ words
...HCV). Medical researchers in Japan have confirmed that estrogen receptors (ERs) on the liver, which modulate estrogen activity...several risk factors for HCV-related liver cancer * Estrogen receptors on the liver may prevent patients with chronic hepatitis...
- Genomic effects of stimulated bone estrogen receptors determined.
- Newspaper article from: Clinical Oncology Week August 16, 2004 700+ words
...The genomic effects of stimulated bone estrogen receptors in osteosarcoma have been determined. "Estrogens...effects in bone, a tissue that contains both estrogen receptors alpha and beta (ERalpha and ERbeta...
