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RU-486 found useful in shrinking fibroids.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- Mifepristone, the drug also known as RU-486 used for early medical abortion, may prove to be an effective alternative treatment for fibroids, according to a new study.
Researchers at the University of Rochester in New York studied 40 women with large fibroids that caused symptoms such as heavy menstrual bleeding, anemia, pelvic pain, bladder pressure, low back pain, and/or painful intercourse.
For 6 months, half of the women took 5 mg of mifepristone daily and the other half took 10 mg daily. (Mifepristone is given at much higher doses when used for medical abortion.) After 6 months, both groups of women experienced comparable shrinking of their fibroids and subsequent improvement in their symptoms. The fibroids had shrunk to about half their original size at the end of the study.
While there were few serious side effects with the use of low-dose mifepristone, some of the women ...
- Low-dose mifepristone blocks pregnancy by altering ovarian function.
- Newspaper article from: Biotech Week March 3, 2004 700+ words
2004 MAR 3 - (NewsRx.com & NewsRx.net) -- Low-dose mifepristone blocks pregnancy by altering ovarian function. "An emergency contraceptive method is used after coitus but before pregnancy occurs...
- Low-dose mifepristone matches GnRH agonists for uterine fibroids.(Six Small...
- Magazine article from: OB GYN News August 1, 2003 700+ words
SCOTTSDALE, ARIZ. -- Low-dose mifepristone taken daily by women with uterine fibroids can significantly reduce fibroid size and symptoms, limited data suggest. The oral...
- New review focuses on emergency contraception.(Report)
- Magazine article from: Contraceptive Technology Update August 1, 2008 700+ words
...with levonorgestrel EC than with mid-dose mifepristone or low-dose mifepristone. Single-dose levonorgestrel EC had...H, Piaggio G, Ding J, et al. Low-dose mifepristone and two regimens of levonorgestrel for...
- Better methods for emergency contraception.
- Magazine article from: OB/GYN Clinical Alert February 1, 2003 700+ words
...emergency contraception. Source: von Hertzen H, et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception...5 days) after unprotected coitus: 10-mg single-dose mifepristone 1.5% pregnancy rate 1.5-mg single-dose levonorgestrel...
- Mifepristone was more effective than the Yuzpe regimen for emergency...
- Magazine article from: Evidence-Based Nursing PW., Ashok C., Stalder January 1, 2003 700+ words
...QUESTIONS: In women seeking emergency contraception, is low dose mifepristone more effective than the Yuzpe regimen in preventing pregnancies...done the first randomised controlled trial comparing lower dose mifepristone (100 mg) with the Yuzpe regimen for emergency contraception...
- Mifepristone enhances glandular androgen receptor expression.
- Newspaper article from: OBGYN & Reproduction Week July 5, 2004 700+ words
...unknown. "We have investigated the effect of daily low-dose mifepristone on proliferation markers and steroid receptors in surface...Journal of Clinical Endocrinology and Metabolism (Low-dose mifepristone inhibits endometrial proliferation and up-regulates androgen...
- Evaluation of the efficacy of mifepristone/misoprostol and...
- Magazine article from: Indian Journal of Medical Sciences Dahiya, K. Madan, S. Hooda, R. Sangwan, K. Khosla, A. July 1, 2005 700+ words
...abortion. OBJECTIVE: To find out the efficacy of low-dose mifepristone and methotrexate for inducing abortion. METHOD: In this...mifepristone group (P < 0.001). CONCLUSION: Low-dose mifepristone and intravaginal misoprostol is safe, effective, and...
- Research eyes options in emergency contraception.
- Magazine article from: Contraceptive Technology Update March 1, 2003 700+ words
...assigned to one of three treatment groups: 10-mg single-dose mifepristone; 1.5-mg single-dose levonorgestrel; or two doses...menstruated earlier than women given mifepristone. "Low dose mifepristone and levonorgestrel regimens had a similar efficacy in our...
- More treatment options available for women requiring emergency contraception.
- Magazine article from: Women's Health Weekly January 2, 2003 700+ words
...5 days of unprotected sexual intercourse. The women were randomly assigned to 1 of 3 treatment groups: 10 mg single-dose mifepristone; 1.5 mg single-dose levonorgestrel; or two doses of 0.75 mg levonorgestrel given 12 hours apart. There were no...
- Making emergency contraceptive use easier.(Service Delivery)(Brief Article)
- Magazine article from: Reproductive Health Matters November 1, 2003 700+ words
...Webb AMC. Emergency contraception. BMJ 2003; 326:775-76. (2.) von Hertzen H, Piaggio G, Ding J, et al. Low dose mifepristone and two regimes of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. Lancet 2002;360...
Source: HighBeam Research, RU-486 found useful in shrinking fibroids.