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Increased risk may be linked to presence of common bacterium in amniotic fluid.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- A scientist at Weill Cornell Medical College has discovered that the presence of the microorganism Ureaplasma urealyticum in the amniotic fluid is linked with an increased risk of preterm labor.
Results from the U.S. National Institutes of Health (NIH)-funded study are published in the Journal of Infectious Diseases.
The study found that U. urealyticum was present in the amniotic fluid of 11.4% of the 254 enrolled women, all of whom were healthy and in their second trimester of pregnancy. Of the women who tested positive for the microbe, 58.6% went on to have preterm labor, compared to 4.4% of women who tested negative. Additionally, women who tested positive for the microbe had a higher prevalence of preterm labor in a prior pregnancy (20.7% vs. 2.7%); this suggests that the microbe may be present in the uterus even prior to conception.
"It remains undertermined whether Ureaplasma directly causes preterm birth, or if it is a marker for another infection," said lead author Dr. Steven S. Witkin, professor of immunology in obstetrics and gynecology at Weill Cornell. "Nevertheless, identification of this microorganism in second trimester amniotic fluids identifies pregnant women at increased risk for a preterm birth."
The test, which employs a DNA amplification technique called polymerase chain reaction (PCR), can also be performed prior to conception on a sample obtained from the uterus. PCR has been established as a superior method to the traditional culture testing method.
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