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Oxidative stress is suspected, due to differences in placental blood flow.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- According to recent research from England, "Onset of the maternal-placental circulation was studied by Doppler ultrasonography in 65 pairs of age matched normal and abnormal pregnancies. In normal pregnancies intervillous blood flow increased with gestational age, being detected in 9/25 cases at 8-9 weeks but in 18/20 at 12-13 weeks (p=0.001).
"By contrast, in abnormal pregnancies, flow was detected in nearly all cases (22/25) at 8-9 weeks (p
The researchers concluded: "Our results indicate that oxidative damage to the trophoblast, induced by premature and widespread onset of the maternal placental circulation secondary to shallow trophoblast invasion, is a key factor in early pregnancy loss. High oxygen concentrations in the periphery of normal early placentas may similarly induce local regression of the villi, leading to formation of the chorion laeve."
Jauniaux and colleagues published their study in American Journal of Pathology (Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol, 2003;162(1):115-125).
For additional information, contact G.J. Burton, University of Cambridge, Department Anatomy, Downing St., Cambridge CB2 3DY, UK.
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Source: HighBeam Research, Oxidative stress is suspected, due to differences in placental blood...