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E-cadherin and beta-catenin expression are downregulated in trophoblast.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- According to recent research from Peoples R China, "E-cadherin and beta-catenin are cell-cell adhesion molecules, which are thought to play an important role in trophoblastic differentiation and remodeling during gestation. Their expression may be altered in pathological conditions with trophoblastic invasion. In this study, we used immunohistochemical methods to study the pattern of expression of E-cadherin and beta-catenin in villous trophoblastic tissue in normal and pathological pregnancies.
"In villous trophoblastic tissue, E-cadherin had a membranous distribution, whereas beta-catenin had a mixed-membranous and granular cytoplasmic distribution. The levels of expression of E-cadherin and beta-catenin correlated with each other. From first to third trimesters, the expression of both E-cadherin and beta-catenin showed a decreasing trend. In preeclampsia, there was an upregulation of E-cadherin and beta-catenin expression. In placenta accreta, the level of expression of both did not differ from that in normal third-trimester placenta," wrote H.W. Li and colleagues.
The researchers concluded: "In gestational trophoblastic diseases, there ...
- A high percentage of liver cancers have elevated liver-intestine cadherin.
- Newspaper article from: Cancer Gene Therapy Week January 19, 2004 700+ words
...the University of Hong Kong. The researchers...liver-intestine cadherin in hepatocellular...Luk, University of Hong Kong, Center Study Liver Diseases, Hong Kong, SAR, Peoples R...Liver-Intestine Cadherin, Gastroenterology...
- Cadherin-11 modulates human trophoblastic cell differentiation in vitro.
- Newspaper article from: OBGYN & Reproduction Week June 23, 2003 700+ words
...JUN 23 - (NewsRx.com & NewsRx.net) -- Cadherin-11 modulates human trophoblastic cell differentiation...published in the journal Developmental Biology, "E-cadherin and cadherin-11 are two members of the cadherin gene family...
- Neural-cadherin expression associates with angiogenesis in lung cancer patients.
- Newspaper article from: Biotech Week July 30, 2003 700+ words
...NewsRx.com & NewsRx.net) -- Neural-cadherin expression associates with angiogenesis in lung...immunohistochemical analysis for E(epithelial)-cadherin and N(neural)-cadherin expression in relation to tumor angiogenesis was...
- Expression of E-cadherin and p53 proteins in human soft tissue sarcomas.
- Magazine article from: Archives of Pathology & Laboratory Medicine Yoo, Jinyoung Park, Sonya Kang, Chang Suk Kang, Seok Jin Kim, Byung Kee January 1, 2002 700+ words
...selectively bind to an identical molecule in a neighboring cell. The cadherin family includes several different members: E (epithelial) cadherin, N (nerve) cadherin, P (placental) cadherin, M (muscle) cadherin, R (retina) cadherin...
- Effects of tumor E-cadherin mutations on Wnt signaling determined.
- Newspaper article from: Science Letter November 16, 2004 700+ words
...The impact of tumor-associated E-cadherin mutations on Wnt signaling has been determined. "E-cadherin is a cell-cell adhesion molecule and...effects of different tumor-derived E-cadherin variants with those of normal E-cadherin...
- E-cadherin loss heightens liver cancer progression in murine models.
- Newspaper article from: Science Letter October 26, 2004 700+ words
...com & NewsRx.net) -- E-cadherin loss heightens liver cancer progression in murine models. "E-cadherin is a cell-cell adhesion molecule...of cell polarity. Disruption of E-cadherin-mediated adhesion represents a key...
- Vascular endothelial-cadherin is a functional regulator of VEGF receptor 2.
- Newspaper article from: World Disease Weekly December 21, 2004 700+ words
...NewsRx.net) -- Vascular endothelial-cadherin is a functional regulator of VEGF receptor 2. "Vascular endothelial (VE)-cadherin plays a critical role in cell-cell...junctions in endothelial cells. VE-cadherin has increasingly been implicated in the...
- WNT7a induces E-cadherin in lung cancer cells.
- Newspaper article from: Biotech Week November 5, 2003 700+ words
...amp; NewsRx.net) -- WNT7a induces E-cadherin in lung cancer cells. "E-cadherin loss in cancer is associated with de-differentiation...invasion, and metastasis. Drosophila DE-cadherin is regulated by Wnt/beta-catenin signaling...