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Viral load could be used as a marker for risk of cervical cancer.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- "HPV infections are believed to be a cause of cervical cancer. Viral burden, as a surrogate indicator for persistence, may help predict risk of subsequent SIL. We used results of Ill test and cytology data, repeated every 4-6 months, in 2081 women participating in a longitudinal study of the natural history of HPV infection and cervical neoplasia in Sao Paulo, Brazil," researchers in Canada report.
"Using the MY09/11 PCR protocol, 473 women were HPV DNA(+) during the first 2 visits. We retested all positive specimens by a quantitative, low stringency PCR method to measure viral burden in cervical cells. Mean viral loads and 95% CIs were calculated using log-transformed data. RRs and 95% CIs of incident SIL were calculated by proportional hazards models, adjusting for age and HPV oncogenicity. The risk of incident lesions increased with viral load at enrollment.
"The mean number of viral copies/cell at enrollment was 2.6 for women with no incident lesions and increased (trend p=0.003) to 15.1 for women developing three or more SIL events over 6 years of followup. Compared to those with <1 copy per cell in specimens tested during the first 2 visits, Ill for incident SIL increased from 1.9 (95% CI 0.8-4.2) for those with 1-10 copies/cell to 4.5 (95% CI 1.9-10.7) for those with>1000 copies/cell. The equivalent RR of HSIL for >1,000 copies/cell was 2.6 (95% CI 0.5-13.2). Viral burden appears to have an independent effect on SIL incidence," wrote N.F. Schlecht and colleagues, ...
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Source: HighBeam Research, Viral load could be used as a marker for risk of cervical cancer.