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ATP activates the mitogen-activated protein kinase in neoplasia.(adenosine triphosphate )
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- Recent research from Canada investigated "the role of ATP in ovarian tumorigenesis, examining the expression of the P2U purinoceptor (P2U-R) and effect of ATP on growth stimulation in preneoplastic and neoplastic ovarian surface epithelial (OSE) cells. The immortalized OSE (IOSE) cell lines, including IOSE-29 (preneoplastic), IOSE-29EC (neoplastic), and OVCAR-3 (ovarian adenocarcinoma cell line) were used. Our results indicated that P2U-R mRNA was expressed and that ATP exerted a growth stimulatory effect in IOSE-29, IOSE-29EC, and OVCAR-3.
"To investigate the mechanism of the growth stimulatory effect, the activation of mitogen activated protein kinases (MAPKs) by ATP was examined. Treatment with ATP resulted in MAPK activation in IOSE-29 and IOSE-29EC cells, whereas the stimulatory effect of ATP in cellular proliferation and MAPK activation was completely abolished in the presence of PD98059 (an MAPK/ERK kinase inhibitor) and staurosporin (a protein kinase C inhibitor), suggesting that the growth stimulatory effect of ATP is mediated via protein kinase C-dependent MAPK activation in preneoplastic and neoplastic OSE cells.
"In a time dependent study, ATP significantly increased MAPK activity at 5-20 min in IOSE-29 cells. Activated MAPK declined to control levels after 20 min in these cells. Treatment with ATP significantly induced MAPK activation after 5 min and was sustained for 60 min in IOSE-29EC cells. In addition, treatment with ATP resulted in substantial phosphorylation of Elk-1, the Ets family transcriptional factor, confirming that ATP ...
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- ATP activates the mitogen-activated protein kinase in neoplasia.
- Newspaper article from: Cancer Gene Therapy Week March 3, 2003 700+ words
...MAPK activation in IOSE-29 and IOSE-29EC cells, whereas...and staurosporin (a protein kinase C inhibitor), suggesting...ATP is mediated via protein kinase C-dependent MAPK...activity at 5-20 min in IOSE-29 cells. Activated...
- ATP activates the mitogen-activated protein kinase in neoplasia.(ovarian cancer)
- Newspaper article from: Cancer Weekly March 4, 2003 700+ words
...MAPK activation in IOSE-29 and IOSE-29EC cells, whereas...and staurosporin (a protein kinase C inhibitor), suggesting...ATP is mediated via protein kinase C-dependent MAPK...activity at 5-20 min in IOSE-29 cells. Activated...
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Source: HighBeam Research, ATP activates the mitogen-activated protein kinase in...