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Expression of p53 and c-erbB-2 differs in two types of cancer.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- "We assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2)," researchers in England report.
"Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p=0.015 and p=0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p=0.013) but not in group 2 (p=0.63) tumors," wrote F. Prefumo and colleagues, General Hospital St. George, School of Medicine.
The researchers concluded: "The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis."
Prefumo and ...
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