AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
TNF-alpha is potential target for treatment intervention.(tumor necrosis factor)
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- According to recent research from New Zealand, "Increased production of PGs by gestational membranes is believed to be a principal initiator of term and preterm labor. Intrauterine infection is associated with an inflammatory response in the choriodecidua characterized by elevated production of cytokines and PGs.
"The precise physiological significance of enhanced choriodecidual cytokine production in the mechanism of preterm labor remains uncertain.
"These studies were undertaken to dissect the roles and regulation of endogenous cytokines in regulating PG production by human choriodecidua. We used LPS treatment of human choriodecidual explants as our model system.
"In choriodecidual explant cultures, LPS (5 microg/ml) induced a rapid increase in tumor necrosis factor (TNF)-alpha production, peaking at 4 h. In contrast, IL-10, IL-1beta, and prostaglandin E[subscript]2 (PGE[subscript]2) production rates peaked 8, 12, and 24 h, respectively, after LPS stimulation.
"Immunoneutralization studies indicated that TNF-alpha was a primary regulator of IL-1beta, IL-10, and PGE[subscript]2 production, while IL-1beta stimulated only PGE[subscript]2 production. Neutralization of endogenous IL-10 resulted in increased TNF-alpha and PGE[subscript]2 production. IL-10 treatment markedly decreased TNF-alpha and IL-1beta production, but had no effect on ...
- Dendritic cells that capture dead tumor cells secrete IL-12 and TNF-alpha.
- Newspaper article from: Biotech Week December 29, 2004 700+ words
...IL-12 and TNF-alpha through IL-12/TNF-alpha/NF-kappa B autocrine...IL-12 secretions, i.e., an IL-12/TNF-alpha/NF-kappaB autocrine...kappaB activation induced by the IL-12/TNF-alpha/NF-kappaB autocrine...
- Microbes modulate IL-6/IL-8/TNF-alpha expression/secretion by oral mucosa cells.
- Newspaper article from: Obesity, Fitness & Wellness Week December 25, 2004 700+ words
...Streptococcus salivarius modulate IL-6/IL-8/TNF-alpha expression and secretion...epithelial cells via two cytokines (IL-6 and TNF-alpha) and one chemokine (IL...analyses revealed that IL-6, IL-8 and TNF-alpha mRNA levels rose in tissues...
- IL-10/TNF alpha region haplotypes predict mortality after unrelated donor SCT.
- Newspaper article from: Medical Devices & Surgical Technology Week August 8, 2004 700+ words
...com & NewsRx.net) -- IL-10 and TNF alpha region haplotypes predict...tumor necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10) gene and TRM." "Both the TNFd4 allele and the TNF-alpha -1031C alleles are...
- Patients and family members of those with LEMS have high serum IL-10, TNF-alpha.
- Newspaper article from: Immunotherapy Weekly October 15, 2003 700+ words
...amp; NewsRx.net) -- High IL-10 and TNF-alpha are found in patients and...we analyzed the production of IL-10 and TNF-alpha after whole blood stimulation...that high innate production of IL-10 and TNF-alpha is a susceptibility factor...
- Levels of cytokines (IL-1[beta], IL-2, IL-6, IL-8, TNF-[alpha]) and trace...
- Magazine article from: Mediators of Inflammation Ustundag, Bilal Yilmaz, Erdal Dogan, Yasar Akarsu, Saadet Canatan, Halit Halifeoglu, Ihsan Cikim, Gurkan Aygun, A. Denizmen January 1, 2005 700+ words
...interleukin [IL]-l[beta], IL-2, IL-6, IL-8, tumor necrosis factor-alpha [TNF-[alpha]]) were determined by...IL]-1[beta], IL-2 IL-6, IL-8, tumor necrosis factor-alpha [TNF-[alpha]]), and trace elements...
- Effects of lichen heteroglycans on proliferation and IL-10 secretion by rat...
- Magazine article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology Omarsdottir, S. Freysdottir, J. Barsett, H. Paulsen, B. Smestad Olafsdottir, E.S. June 1, 2005 700+ words
...the heteroglycans stimulated TNF-[alpha] secretion, but not IL-10 secretion. These results...Spleen cell proliferation; IL-10; TNF-[alpha]; Immunomodulating...10 by rat spleen cells and TNF-[alpha] and IL-10 production by rat peritoneal...
- Brucella abortus induces TNF and IL-12p40 by MyD88-dependent pathways.
- Newspaper article from: Health & Medicine Week September 15, 2003 700+ words
...killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent...killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is toll-like...
- Human IL-2 and Bovine TNF alpha Screening Sets.(Immunological Reagents & Kits)
- Magazine article from: Bioscience Technology February 1, 2005 700+ words
Human IL-2 and Bovine TNF alpha Screening Sets are offered...gamma] IL-1[beta] IL-6, IL-8 and TNF[alpha]; bovine IFN[gamma...gamma] and MCP-1; porcine TNF[alpha]; and primate IL-1[beta] and TNF[alpha...
