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Hormone replacement maintains vaginal integrity after ovarian removal.

Women's Health Weekly

| March 06, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 MAR 6 - (NewsRx.com & NewsRx.net) -- "The goal of this study was to investigate the effects of ovariectomy and estrogen replacement on vaginal tissue integrity and vaginal lubrication in basal conditions and in response to pelvic nerve stimulation (PNS)," researchers in the United States reported.

"Two weeks after ovariectomy, female New Zealand White rabbits were administered vehicle or estradiol ( 200 micrograms/day) for an additional 2 weeks. Ovariectomy caused significant vaginal atrophy and diminished vaginal lubrication in the basal state and after PNS, compared to intact controls," wrote K. Min and colleagues, Boston University, School of Medicine.

"Estrogen replacement normalized lubrication values and tissue wet weight to control levels. Vaginal tissue integrity and lubrication are diminished by ovariectomy and are normalized by estrogen replacement," ...

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