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Growth arrest of HPV-positive cells is independent of E6/E7 oncogene expression.(human papilloma virus)
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- "Inhibitors of histone deacetylase (HDAC) are capable of arresting growth in cervical carcinoma cells in the G1 phase of the cell cycle. Although HPV E6/E7 mRNA steady-state levels appeared to be constant after prolonged treatment, time-course experiments revealed that viral transcription was transiently down-regulated between 7-10 h prior to cdk2 suppression.
"To test whether transitory suppression was a prerequisite for the biological outcome after HDAC inhibition, we took advantage of two immortalized human keratinocyte cell lines in which E6/E7 oncogene expression was controlled by different regulatory regions," researchers in Germany report.
"After treatment with sodium butyrate (NaB) or trichostatin A (TSA), HPV16 upstream regulatory region (URR)-directed transcription was down-regulated, showing kinetics similar to those in cervical carcinoma cells. In contrast, P-actin promoter controlled E6/E7 transcription was even temporarily increased and finally declined to levels initially detected in the untreated controls.
"Both cell lines, however, were arrested in G1 and showed complete suppression of cdk2 activity that was preceded by a strong up-regulation of the cdk2 inhibitors p21(CIP1) and p27(KIP1)," wrote P. Finzer and colleagues, Deutsch Krebsforschungszentrum, Forschungsschwerpunkt Angew Tumorvirology.
The ...
- Growth arrest of HPV-positive cells is independent of E6/E7 oncogene expression.
- Newspaper article from: Immunotherapy Weekly March 5, 2003 700+ words
...and colleagues, Deutsch Krebsforschungszentrum, Forschungsschwerpunkt Angew Tumorvirology. The researchers...report is P. Finzer, Deutsch Krebsforschungszentrum, Forschungsschwerpunkt Angew Tumorvirology, Abt Tumorvirusimmunol...
- Human papillomavirus oncoproteins E6 and E7 function to resist apoptosis.
- Newspaper article from: Proteomics Weekly February 10, 2003 700+ words
...and colleagues, Deutsch Krebsforschungszentrum, Forschungsschwerpunkt Angew Tumorvirology. Finzer and colleagues...report is F. Rosl, Deutsch Krebsforschungszentrum, Forschungsschwerpunkt Angew Tumorvirology, Abt Tumorvirusimmunol...
- HDAC inhibitors trigger apoptosis in HPV+ cells by inducing E2F-p73 pathway.
- Newspaper article from: Immunotherapy Weekly September 1, 2004 700+ words
...23(28):4807-4817). For additional information, contact P. Finzer, Deutsch Krebsforschungszentrum, Forschungsschewerpunkt Angew Tumorvirology, Abt Virale Transformat Mech, Neuenheimer Feld 242, D-69120 Heidelberg, Germany...
- Binding of virus capsids from to integrin analyzed, specificity reported.
- Newspaper article from: Immunotherapy Weekly December 29, 2004 700+ words
...wrote J. Langner and colleagues, Deutsch Krebsforschungszentrum. "Ten mutants gave rise to the expected...information, contact M. Pawlita, Deutsch Krebsforschungszentrum, Research Program for Infection...
- Cell lines characterized by frequent aberrations on chromosomes 2p, 9p.
- Newspaper article from: Genomics & Genetics Weekly March 7, 2003 700+ words
...stated S. Joos and coauthors, Deutsch Krebsforschungszentrum. "Furthermore, multiple translocated...author for this report is S. Joos, Deutsch Krebsforschungszentrum, H0700, Neuenheimer Feld 280, D...
- Novel AP-1 target genes identified in cutaneous-repair fibroblasts.
- Newspaper article from: Health & Medicine Week November 22, 2004 700+ words
...noted L. Florin and colleagues at the Deutsch Krebsforschungszentrum in Heidelberg. "To identify AP...additional information, contact P. Angel, Deutsch Krebsforschungszentrum, Division of Signal Transduction and...
- Novel fast flow velocity measurement technique devised.
- Newspaper article from: Medical Devices & Surgical Technology Week October 31, 2004 700+ words
...conducted by S. Volz and coauthors at the Deutsch Krebsforschungszentrum, a fast flow measurement technique...additional information, contact M. Bock, Deutsch Krebsforschungszentrum, Abt. Medizinische Physik in der...
- Radial Na-MRI provides a tool for clinical studies.
- Newspaper article from: Biotech Week September 29, 2004 700+ words
...sodium." R. Jerecic and colleagues of Deutsch Krebsforschungszentrum wrote, "As the in vivo sodium signal...information, contact R. Jerecic, Deutsch Krebsforschungszentrum, Abteilung Biophysik und Medizinische...
