AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Papillomavirus' E6 and E7 proteins differentially protect from cell apoptosis.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Cervical cancer cells express high risk human papillomavirus (HPV) E6 and E7 proteins, and repression of HPV gene expression causes the cells to cease proliferation and undergo senescence. However, it is not known whether both HPV proteins are required to maintain the proliferative state of cervical cancer cells, or whether mutations which accumulate during carcinogenesis eliminate the need for one or the other of them. To address these questions, we used the bovine papillomavirus E2 protein to repress the expression of either the E6 protein or the E7 protein encoded by integrated HPV18 DNA in HeLa cervical carcinoma cells.
"Repression of the E7 protein activated the Rb pathway but not the p53 pathway and triggered senescence, whereas repression of the E6 protein activated the p53 pathway but not the Rb pathway and triggered both senescence and apoptosis. Telomerase activity, cyclin dependent kinase activity, and expression of c-myc were markedly inhibited by repression of either E6 or E7," wrote R.A. Defilippis and colleagues, Yale University, School of Medicine.
The researchers concluded: "These results demonstrate that continuous expression of both the E6 and the E7 protein is required for optimal ...
- Research findings from Yale University update understanding of cervical...
- Newspaper article from: Cancer Weekly August 18, 2009 700+ words
...and colleagues, Yale University (see also Cervical Cancer). The researchers...L. Brandsma, Yale University, School Medical...Carcinogenesis, Cervical Cancer, Cervical Carcinoma...Women's Health, Yale University. This article...
- Studies from Yale University, Medical Department in the area of cervical cancer...
- Newspaper article from: Clinical Trials Week August 3, 2009 700+ words
...therapy in cervical cancer can predict...colleagues, Yale University, Medical Department (see also Cervical Cancer). The researchers...Celecoxib, Cervical Cancer, Cervical...s Health, Yale University, Medical Department...
- Data on cancer vaccines published by researchers at Yale University, Medical...
- Newspaper article from: Cancer Vaccine Week August 24, 2009 700+ words
...HPV-infected cervical cancer," wrote S...colleagues, Yale University, Medical Department...Tumor Cells in Cervical Cancer Patients: Implications...D. Santin, Yale University, School Medical...Cancer Vaccines, Cervical Cancer, Cervical Carcinoma...s Health, ...
- Papillomavirus' E6 and E7 proteins differentially protect from cell...
- Newspaper article from: Cancer Weekly March 4, 2003 700+ words
...maintain the proliferative state of cervical cancer cells, or whether mutations...Defilippis and colleagues, Yale University, School of Medicine. The researchers...under the major subject areas of Cervical Cancer, Genetics, Gynecology, Infectious...
- Health Highlights: July 9, 2009; Heart Patient Death Rates Vary Widely in U.S.:...
- News wire article from: Consumer Health News (English) July 9, 2009 700+ words
...lowest rates, says a Yale University School of Medicine study...WHO Approves 2nd Cervical Cancer Vaccine A second cervical cancer vaccine has been approved...where most deaths from cervical cancer occur. Cervarix is made...
- Researchers Report That Phenoxodiol Produces Anti-Cancer Responses in Women...
- Press release article from: PR Newswire November 17, 2005 700+ words
...FirstCall/ -- Researchers from Yale University's School of Medicine reported today...tumor. The researchers observed that cervical cancer tissue may contain the necessary deconjugating...Professor Kelly said. "These data with cervical cancer provide evidence that orally- ...
- Marshall Edwards, Inc. Commences Clinical Trial in Cervical Cancer at Yale.
- Press release article from: PR Newswire February 23, 2004 700+ words
...Investigator is Dr. Masoud Azodi of the Yale University School of Medicine. The subjects...trial should contact Renee Luongo at Yale University School of Medicine, 203-785-6956...of phenoxodiol in a precise way. "Cervical cancer is a squamous cell carcinoma, which...
- Findings from Yale University, Medical Department advance knowledge in...
- Newspaper article from: Cancer Weekly December 8, 2009 700+ words
...and colleagues, Yale University, Medical Department...contacting N. Buza, Yale University, School Medical...Adenocarcinoma, Cervical Cancer, Cervical Carcinoma...Women's Health, Yale University This article was...
Source: HighBeam Research, Papillomavirus' E6 and E7 proteins differentially protect from cell...