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Gender and hormonal status modulate the effects of psyllium in humans.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- The effects of psyllium on plasma cholesterol and triglyceride levels tend to depend on a person's gender and hormonal status, according to new research from the United States.
"Psyllium (PSY) intake decreases plasma low-density lipoprotein (LDL) cholesterol (LDL-C) in men and pre- and postmenopausal women while PSY effects on plasma triglycerides (TG) are sex related. A significant decrease in plasma TG was observed in men while postmenopausal women experienced an increase in plasma TG concentrations following PSY supplementation," according to S. Vega-Lopez and colleagues, University of Connecticut, Department of Nutritional Sciences.
"To further explore the mechanisms by which sex and hormonal status influence the effects of PSY on plasma lipids, HMG-CoA reductase, LDL receptor and lipoprotein lipase (LPL) mRNA abundance were measured in mononuclear cells isolated from these subjects," researchers said.
"The intervention followed a randomized crossover design in which participants were allocated to either 15 or 0 g (control) of PSY/day for 30 days. Compared to the control period, PSY intake induced a 20% increase in HMG-CoA reductase mRNA abundance (p
"These results suggest that the LDL-C lowering induced by PSY was related to changes ...
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Source: HighBeam Research, Gender and hormonal status modulate the effects of psyllium in humans.