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Foreign DNA prevents mammary adenocarcinoma in transgenic mice.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- Researchers in Italy have identified antisense oligodeoxynucleotides that not only treat but also prevent mammary adenocarcinomas in transgenic mice by heightening the innate immune response system.
According to a study from Italy, "unmethylated CpG-oligodeoxynucleotides (CpG-ODNs) are recognized as a 'danger signal' and are potent immunostimulators. To test whether tumors might be prevented by maintaining the innate immune system on continuous alert, proto-neutransgenic female mice, which develop spontaneous mammary tumors, were systemically treated with CpG-ODNs at 10-day intervals."
"Tumor incidence and number of tumors/mouse were significantly lower in treated mice compared with the control group," reported L. Sfondrini and coauthors, National Tumor Institute, Department of Experimental Oncology.
"Moreover, CpG-ODN systemic treatment significantly reduced lung metastases induced by intravenous inoculation of N202.1A cells derived from a spontaneous mammary carcinoma. Growth of established tumors was modestly inhibited after CpG-ODN systemic treatment but strongly on peritumoral application."
"Our data indicate that systemic repeated injection ...
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Source: HighBeam Research, Foreign DNA prevents mammary adenocarcinoma in transgenic mice.