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Protein is overexpressed in endothelial cells of mouse breast tumor vessels.
2003 MAR 6 - (NewsRx.com & NewsRx.net) -- According to recent research from Switzerland, "angiogenesis is a key process in a variety of human diseases, including cancer. The ability to target selectively the tumor vasculature is potentially useful for the diagnosis and treatment of cancer. Still, little information is available regarding markers that are restricted to the endothelial cells of tumor vessels."
"cDNA array technology allows simultaneous analysis of relative expression levels of a broad spectrum of genes in two related cell populations. We used this technology with the aim of identifying markers specific for tumor ECs (TECs)," wrote M.C. Schmid and colleagues, University of Bern.
"TECs were isolated by CD31-mediated immunomagnetic separation from tumors induced by subcutaneous injection of NF9006 breast carcinoma cells into syngeneic mice. Normal ECs (NECs) were isolated from lactating mammary glands. The endothelial nature of isolated cells was confirmed by RT-PCR using CD31-specific primers and by uptake of Dil-Ac-LDL," researchers said.
"Macrophage contamination in the EC isolations could be reasonably ruled out by assessing the expression of the macrophage marker c-fms. P-32-labeled cDNA probes generated by reverse transcription from total RNA were hybridized to mouse-specific gene arrays. Several genes consistently showed differential expression between TECs and NECs."
"However, expression of only one of ...
- Liposomal surface charge dictates uptake by angiogenic tumor vessels.
- Newspaper article from: Biotech Week July 16, 2003 700+ words
...uptake in angiogenic tumor vessels and therefore may...published their study in International Journal of Cancer (Effect...uptake by angiogenic tumor vessels. Int J Cancer...publisher of the International Journal of Cancer can be...
- Protein is overexpressed in endothelial cells of mouse breast tumor vessels.
- Newspaper article from: Angiogenesis Weekly March 7, 2003 700+ words
...endothelial cells of tumor vessels." "cDNA array...published their study in International Journal of Cancer (Insulin...of mouse breast tumor vessels. Int J Cancer...subscribe to the International Journal of Cancer, contact...
- Antisense therapy sends signals that form wedge against tumor vessels.
- Newspaper article from: Gene Therapy Weekly July 18, 2002 700+ words
...antisense treatment of human HNSCC cell lines down-regulates VEGF expression and endothelial cell migration, International Journal of Oncology, July 2002;21(10):11-16). Identifying ways to limit EGFR signaling in head and neck...
- Normalizing tumor vessels to improve cancer therapy.
- Newspaper article from: Angiogenesis Weekly September 12, 2008 700+ words
...leakiness. "These abnormal features of tumor vessels impair delivery of circulating chemotherapeutic...vascular pattern formation. Because tumor vessels are malformed, Ghosh wondered whether...contractility in the formation of irregular tumor vessels, and have identified potential ...
- Renal cancer tumor vessels express a member of the RGS superfamily.
- Newspaper article from: Angiogenesis Weekly July 2, 2004 700+ words
...amp; NewsRx.net) -- Renal cancer tumor vessels express a member of the RGS superfamily...protein signaling protein 5 (RGS5) in tumor vessels in human renal cell carcinoma (RCC...in G protein-mediated signaling in tumor vessels in human RCC," researchers concluded...
- Hormone receptor status and tumor vessels change with endometrial progression.
- Newspaper article from: Angiogenesis Weekly January 16, 2004 700+ words
...net) -- Hormone receptor status and tumor vessels change with endometrial progression...study were to identity the roles of tumor vessels and hormone receptor status in normal...Significance of hormone receptor status and tumor vessels in normal, hyperplastic and neoplastic...
- Recombinant antibody directs interleukin-2 to tumor vessels.(Brief Article)
- Newspaper article from: Cancer Weekly April 2, 2002 700+ words
...therapeutic molecules to newly forming tumor vessels," explained Carnemolla and coauthors...antibody specifically associates with tumor vessels. They call the fusion protein L19...called L19, shows special affinity for tumor vessels * When a fusion protein consisting...
- Recombinant antibody directs interleukin-2 to tumor vessels.
- Newspaper article from: Angiogenesis Weekly April 5, 2002 700+ words
...therapeutic molecules to newly forming tumor vessels," explained Carnemolla and coauthors...antibody specifically associates with tumor vessels. They call the fusion protein L19...called L19, shows special affinity for tumor vessels * When a fusion protein consisting...